What is the drug tamoxifen used for?
Tamoxifen is an effective hormone therapy used to treat hormone receptor-positive breast cancer. It can greatly reduce the risk of cancer recurrence and invasive cancer.
What is tamoxifen mechanism of action?
Tamoxifen (TAM) is known to have a dual mechanism of action: (1) to compete with 17β-estradiol (E2) at the receptor site and to block the promotional role of E2 in breast cancer; and (2) to bind DNA after metabolic activation and to initiate carcinogenesis.
What is tamoxifen structure?
Tamoxifen | C26H29NO – PubChem.
What class of drug is tamoxifen?
Tamoxifen is in a class of medications known as antiestrogens. It blocks the activity of estrogen (a female hormone) in the breast.
Does tamoxifen stop period?
For some women, continued use of tamoxifen means periods become less regular, lighter or stop altogether. Generally, your periods will start again once you stop taking tamoxifen, as long as you have not gone through the menopause naturally while taking the drug.
Is tamoxifen a safe drug?
All drugs have risks and side effects that must be discussed when making the decision about chemoprevention. Most experts agree that tamoxifen and raloxifene should not be used to reduce breast cancer risk in women who: Have a higher risk of serious blood clots* Are pregnant or planning to become pregnant.
What is the target of tamoxifen?
The review describes tamoxifen targets, whose blocking induces inhibition of tumor cell growth and angiogenesis, stimulation of the programmed cell death (apoptosis, autophagia and necrosis), inhibition of multiple drug resistance mechanism and inhibition of invasion and metastasizing.
How is tamoxifen metabolized?
Tamoxifen is metabolized via CYP2D6 into endoxifen (4-OH-N-desmethyl-tamoxifen), its primary active metabolite. Multiple investigations have identified genetic variants of CYP2D6 that can affect its activity, which in turn affects the metabolism of tamoxifen.
Is tamoxifen an antibody treatment?
Tamoxifen is a widely known anti-estrogen which has been employed in adjuvant treatment of early-stage, estrogen-sensitive breast cancer for over 20 years.
Can I take vitamin C with tamoxifen?
No interactions were found between tamoxifen and Vitamin C.