What kind of antibiotic is fosfomycin?
Fosfomycin is a broad spectrum bactericidal antibiotic that interferes with cell wall synthesis in both Gram-negative and Gram-positive bacteria (11).
What is the use of fosfomycin?
Fosfomycin is indicated for the treatment of acute uncomplicated lower urinary tract infections in adults, caused by pathogens sensitive to fosfomycin.
Is fosfomycin a penicillin?
Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by Streptomyces fradiae.
Can fosfomycin be taken daily?
Since fosfomycin is used as a single dose, it does not have a daily dosing schedule.
Is fosfomycin good for prostatitis?
An oral regimen of fosfomycin tromethamine of 3 g·q 24 h for one week followed by 3 g·q 48 h for a total treatment duration of 6–12 weeks appeared to be effective. Oral fosfomycin may represent an efficacious and safe treatment for acute and chronic prostatitis caused by MDR E. coli.
Is fosfomycin good for kidney infection?
Fosfomycin inhibits the growth of bacteria in a wide range of concentration (50-1000 microgram/ml). A prospective study in vivo shows an excellent therapeutic action of fosfomycin in recurrent urinary infections, and a very good one in CPN and in some forms associated to kidney stones.
When did fosfomycin become an essential medicine?
Fosfomycin was discovered in 1969 and approved for medical use in the United States in 1996. It is on the World Health Organization’s List of Essential Medicines. The World Health Organization classifies fosfomycin as critically important for human medicine. It is available as a generic medication.
How does fosfomycin inhibit bacterial cell wall biogenesis?
Fosfomycin is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA.
Are there any enzymes that are resistant to fosfomycin?
Fosfomycin resistance enzymes. Enzymes conferring resistance to fosfomycin have also been identified and are encoded both chromosomally and on plasmids. Three related fosfomycin resistance enzymes (named FosA, FosB, and FosX) are members of the glyoxalase superfamily. These enzymes function by nucleophilic attack on carbon 1 of fosfomycin,…