Which pathophysiologic mechanism is associated with multiple sclerosis?
The underlying pathophysiology hallmarks are inflammatory lesions that result in neuronal demyelination, axonal damage and subsequent neurological dysfunctions following the formation of multiple plaques in the grey and white matter of the brain and spinal cord (9).
Which are the most commonly reported clinical manifestations of multiple sclerosis?
More common symptoms
- MS Hug (Dysesthesia) Often a first symptom of MS or a relapse, an MS hug is a squeezing sensation around the torso that feels like a blood pressure cuff when it tightens.
- Fatigue.
- Walking (Gait) Difficulties.
- Numbness or Tingling.
- Spasticity.
- Weakness.
- Vision Problems.
- Vertigo and Dizziness.
Is MS motor or sensory?
Classic MS symptoms are as follows: Sensory loss (ie, paresthesias) – Usually an early complaint. Spinal cord symptoms (motor) – Muscle cramping secondary to spasticity. Spinal cord symptoms (autonomic) – Bladder, bowel, and sexual dysfunction.
What is the main mechanism of multiple sclerosis?
The mechanism of demyelination in multiple sclerosis may be activation of myelin-reactive T cells in the periphery, which then express adhesion molecules, allowing their entry through the blood-brain barrier (BBB).
What do scientists hypothesized to be the causes of MS?
The cause of multiple sclerosis is unknown. It’s considered an autoimmune disease in which the body’s immune system attacks its own tissues. In the case of MS , this immune system malfunction destroys the fatty substance that coats and protects nerve fibers in the brain and spinal cord (myelin).
Is MS on both sides of body?
So in a way, if you really think about it, while MS can attack and affect only one side of the body, it still affects both sides in the long run.
Does MS affect one side or both?
It usually happens in the face, arms, or legs, and on one side of the body. It also tends to go away on its own.
Where can I find information on Dyschromatosis hereditaria?
Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. PubMed is a searchable database of medical literature and lists journal articles that discuss Dyschromatosis universalis hereditaria. Click on the link to view a sample search on this topic.
Which is autosomal dominantly inherited disorder ( Duh )?
Dyschromatosis universalis hereditaria (DUH) is usually an autosomal dominantly inherited disorder characterized by the presence of hypopigmented as well as hyperpigmented macules. We report an Indian patient with DUH with widespread involvement of skin including the face, oral mucous membranes (including tongue), and palms and soles.
Which is a rare genetic disorder of the skin?
A rare, genetic, pigmentation anomaly of the skin characterized by generalized, irregularly shaped, asymptomatic, hyper- and hypopigmented macules distributed in a reticular pattern involving the trunk, limbs, and sometimes the face. The palms, soles and mucosa are usually not affected. Systemic abnormalities have been rarely reported.