What are the 5 stages of endochondral ossification?
Endochondral Ossification
- Reserve Zone. Storage site for lipids, glycogen, proteoglycan.
- Proliferative Zone. Proliferating chondrocytes leading to longitudinal growth.
- Hypertrophic Zone. Site of chondrocyte maturation.
- Primary Spongiosa. Site for mineralization to form woven bone.
- Secondary Spongiosa.
What is the process of endochondral ossification?
Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. At the same time, the cartilage in the center of the diaphysis begins to disintegrate. Osteoblasts penetrate the disintegrating cartilage and replace it with spongy bone. This forms a primary ossification center.
What bones form through intramembranous ossification?
Intramembranous ossification is the process of bone development from fibrous membranes. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles.
What is the process of ossification of bone?
Osteogenesis/ossification is the process in which new layers of bone tissue are placed by osteoblasts. Endochondral bone formation occurs when hyaline cartilage is used as a precursor to bone formation, then bone replaces hyaline cartilage, forms and grows all other bones, occurs during development and throughout life.
What are the 7 steps of endochondral ossification?
7 steps:
- Development of the cartilage model.
- Growth of the cartilage model.
- Development of the primary ossification center.
- Development of the Medullary cavity.
- Secondary ossification centers.
- Formation of articular cartilage & epiphyseal plate.
- Closure of Growth Plate (epiphyseal plate hardens)
What are the 6 major steps in endochondral ossification?
Terms in this set (6)
- Cartilage enlarges; Chondrocytes die.
- blood vessels grow into perichondrium; cells convert to osteoblasts; shaft becomes covered with superficial bone.
- more blood supply and osteoblasts; produces spongy bone; formation spreads on shaft.
- Osteoclasts create medullary cavity; appositional growth.
What are the 5 steps of ossification in a long bone?
Terms in this set (5)
- hyaline cartilage is completly covered with bone matrix by osteoblasts.
- cartilage is digested away by osteoclasts, opening up a medullary cavity within the bone.
- blood vessels, neves, and osteoblasts, and osteoclasts, invade the internal shaft and spongy bone is formed.
What forms Embryonically from?
Embryonic/fetal development proceeds from rostral (nose and mouth area) to caudal (posterior). The skull and vertebral column are produced by intramembranous ossification. As development proceeds down the body axis, the long bones of the arms and legs are produced by endochondral ossification.
What are the 6 steps of endochondral ossification?
How is cartilage replaced in endochondral ossification?
In endochondral ossification, bone develops by replacing hyaline cartilage. Cartilage does not become bone. Instead, cartilage serves as a template to be completely replaced by new bone. Endochondral ossification takes much longer than intramembranous ossification.
How is bone formed in a cartilage model?
The process of bone formation in pre-existing cartilage models is known as endochondral ossification. In this ossification process, the calcified cartilage is replaced by the bone. This is a complex process to form a bone where you will find two ossification centers.
How does intramembranous ossification of the bone occur?
Intramembranous Ossification This process involves the direct conversion of mesenchyme to the bone. It begins when neural crest-derived mesenchymal cells differentiate into specialized, bone-forming cells called osteoblasts. Osteoblasts group into clusters and form an ossification center.
How is cartilage invaded by the ossification front?
The invasion of cartilage matrix by the ossification front is dependent on its resorption by members of the matrix metalloproteinase family, as well as the presence of blood vessels and bone-resorbing osteoclasts.