Does fexofenadine cause QT prolongation?
Until now, fexofenadine was not associated with QT prolongation. Early safety data from studies in animals and humans indicated that concomitant exposure to erythromycin and ketoconazole resulted in raised fexofenadine levels but no increase in QT time.
What antihistamines cause long QT syndrome?
Some antihistamines, such as mizolastine and ebastine, can prolong the QT interval and provoke severe cardiac arrhythmias. This review examines the effects of two widely used antihistamines, cetirizine and loratadine, on the QT interval.
What allergy medicine can I take with long QT syndrome?
Diphenhydramine, orphenadrine and hydroxyzine are contra-indicated. No accidents and no effects on the QT interval have been published for ebastine, fexofenadine, desloratadine and levocetirizine.
Does fexofenadine cause tachycardia?
Increased heart rate (tachycardia). Diarrhoea. Skin reactions such as rash and itching. Allergic reactions to the medicine, which may cause swelling of the face, lips, tongue or throat, difficulty breathing, chest tightness or flushing.
Is fexofenadine safe for cardiac patients?
Safety: adverse clinical cardiovascular events: No Heart rate and rhythm adverse events were 0.3% in fexofenadine HCl patients (8 of 2,319) and 0.1% in placebo patients (1 of 671).
Do all antihistamines cause QT prolongation?
Antihistamines: Nonsedating antihistamines were considered potential causes of QT prolongation. Terfenadine and astemizole were found to have proarrhythmic effects, which led to their withdrawal from the market in 1998 and 1999, respectively.
Is QT prolongation reversible?
Some forms of long QT syndrome result from a genetic mutation that is passed down through families (inherited). If an underlying medical condition or medication causes it, it’s called acquired long QT syndrome. This type of long QT syndrome is usually reversible when the underlying cause is identified.
How do antihistamines prolong QT?
The histamine H1 receptor antagonist diphenhydramine inhibits the fast sodium channels and at higher concentrations inhibits the repolarizing potassium channels which leads to prolongation of the action potential and the QT interval.
Is fexofenadine safe for heart?
The thorough and systematic evaluation of the safety of fexofenadine HCl relevant to cardiac conduction, with particular attention to QTc prolongation, indicates that fexofenadine HCl has no significant effect on QTc, even at doses many times higher than indicated, and at treatment durations of up to 12 months.
How long does fexofenadine prolong QTc interval in rabbits?
Fexofenadine did not prolong QTc in dogs when administered at a dosage of 10 mg/kg/day orally for 5 days or in rabbits when administered at a dosage producing plasma concentrations at least 28 and 63 times greater than those seen after administration of therapeutic dosages (60 mg twice daily) in humans.[3,11]
When does a ventricular tachycardia occur after fexofenadine withdrawal?
Carvedilol, known to protect the heart via its β-blocking properties, had been discontinued. The first recorded episode of ventricular tachycardia occurred during a fexofenadine-free interval, 4 days after withdrawal of fexofenadine (mean terminal elimination half-life 11–16 h).
What are the cardiotoxic effects of terfenadine and astemizole?
The cardiotoxic effects of the two withdrawn drugs, terfenadine and astemizole, were manifested by prolonged QT intervals and triggering torsades de pointes (TdP) caused by blockade of the ‘rapid’ IKrpotassium channels. These phenomena, however, are not a class effect.