How effective is Navelbine?
A phase 2 clinical trial that is studying the effectiveness of navelbine (vinorelbine) as a single-agent first-line treatment is showing a partial response rate of 24%, a stable disease rate of 55% with 21% of patients experiencing disease progression during treatment.
How long does letrozole work for metastatic breast cancer?
Letrozole helps stop your breast cancer coming back. By taking this medicine for 5 years (or sometimes up to 10 years), you have a better chance of being alive 15 years after your breast cancer was first diagnosed.
Which hormone is given for palliative treatment of metastatic breast cancer?
At present, tamoxifen is the drug of choice as first-line endocrine therapy for metastatic breast cancer with no or minimal symptoms in premenopausal or postmenopausal women.
What is Navelbine used to treat?
Vinorelbine is a chemotherapy drug used to treat breast cancer. It’s also known by the brand name Navelbine.
How often is Navelbine given?
The recommended dosage of NAVELBINE is 30 mg/m2 administered as an intravenous injection or infusion over 6 to 10 minutes once a week in combination with cisplatin 120 mg/m2 on Days 1 and 29, then every 6 weeks.
What does topotecan hydrochloride do?
Topotecan is a chemotherapy drug and is also known by its brand names, Hycamtin and Potactasol. It is a treatment for: ovarian cancer that has spread to other parts of the body. small cell lung cancer that has come back or spread.
What is the success rate of letrozole?
In the intention-to-treat analysis, women who received letrozole alone had a disease-free survival rate of 73.8 percent at 8 years, compared with a rate of 70.4 percent for women who received tamoxifen alone.
Can letrozole shrink tumors?
For example, women whose tumors made or ‘expressed’ either of these proteins (ErbB-1 or ErbB-2) appeared to be largely resistant to the effects of tamoxifen, the study showed. Letrozole, however, was very effective in these types of tumors, shrinking them in 88 percent of women.
Is Navelbine a Vesicant?
Vinorelbine is given through a vein by intravenous injection (IV push) or infusion (IV). There is no pill form. Vinorelbine is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein.
How do I give Navelbine?
Administer diluted NAVELBINE over 6 to 10 minutes into the side port of a free-flowing intravenous line followed by flushing with at least 75 to 125 mL of one of the solutions. NAVELBINE must only be administered intravenously.
How is Navelbine used to treat breast cancer?
How it works: Vinca alkaloids kill cancer cells by interfering with genes and stopping the cells from reproducing themselves. Uses: Navelbine is used to treat advanced-stage breast cancer. How it’s given: Navelbine is given intravenously. Additional information: Navelbine is made from the periwinkle plant.
Can you use vinorelbine in first line breast cancer?
Taken together, these data indicate that oral vinorelbine is a highly effective and well tolerated agent which can be used in first-line and subsequent metastatic breast cancer settings. Moreover, this compound may offer the specific advantages of oral chemotherapy, as fewer and shorter hospital vis …
Which is the best vinca alkaloid for breast cancer?
Background: Vinorelbine (Navelbine), a new vinca alkaloid, is an effective drug in breast cancer. Our study was undertaken to assess the efficacy and tolerance of Navelbine in refractory advanced and/or metastatic breast cancer (AMBC).
Which is better oral Navelbine or intravenous vinorelbine?
Oral navelbine as single agent in first-line MBC has the same efficacy of intravenous vinorelbine in phase II studies in terms of OR, duration of response, progression-free survival and overall survival, and is well tolerated with a manageable gastrointestinal toxicity (8% of G3-4 N/V without prophylactic antiemetic treatment) [ 5 ].