What is the mechanism of action of oseltamivir?
Mechanism of Action Oseltamivir inhibits the neuraminidase enzyme, which is expressed on the viral surface. The enzyme promotes release of virus from infected cells and facilitates viral movement within the respiratory tract.
What are the functional groups in oseltamivir?
The functional groups present in the compound are:
- Alkene: A double bond shown in red.
- Ether: The ether group shown in green. In ether, an oxygen atom is linked to two carbon groups.
- Ester: One ester shown in blue.
- Amide: One amide functional group shown in light blue.
- Amine: An amine functional group is shown in pink.
How is oseltamivir made?
How is Tamiflu made? The starting material for the drug is shikimic acid, which is present in the pods of star anise. The high demand for the drug means that it is now made using bacterial fermentation methods. Tamiflu is a prodrug, usually administered as oseltamivir phosphate and swallowed as a pill.
What type of drug is oseltamivir?
A. Tamiflu (oseltamivir phosphate) is an antiviral drug. It works by attacking the flu virus to keep it from multiplying in your body and by reducing the symptoms of the flu. Tamiflu can sometimes keep you from getting the flu if you take it before you get sick.
What is the indication of oseltamivir?
Indication. TAMIFLU is indicated for the treatment of acute, uncomplicated illness due to influenza A and B infection in patients 2 weeks of age and older who have been symptomatic for no more than 48 hours. TAMIFLU is indicated for the prophylaxis of influenza A and B in patients 1 year and older.
What is the mechanism of acyclovir?
Mechanism of Action: Acyclovir is converted to its triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.
How many functional groups are in oseltamivir?
five functional groups
To help Hiro out CIRCLE five functional groups in Tamiflu and NAME THEM.
Is oseltamivir a protein?
Oseltamivir (Tamiflu) is one of three licensed medications that specifically target the neuraminidase protein common to influenza A and B viruses. Oseltamivir is an ethyl ester prodrug that, after hydrolysis by hepatic esterases, is converted to the active compound, oseltamivir carboxylate.
What is the role of oseltamivir?
Oseltamivir is in a class of medications called neuraminidase inhibitors. It works by stopping the spread of the flu virus in the body. Oseltamivir helps shorten the time that flu symptoms such as a stuffy or runny nose, sore throat, cough, muscle or joint aches, tiredness, headache, fever, and chills last.
Is oseltamivir a penicillin?
The Food and Drug Administration (FDA) issued a warning about a potentially harmful product sold over the Internet as “generic Tamiflu.” FDA tests revealed that the product in question does not contain Tamiflu’s active ingredient, oseltamivir, but cloxacillin, an ingredient in the same class of antibiotics as …
What is tab oseltamivir?
Oseltamivir is used to treat symptoms caused by the flu virus (influenza). It helps make the symptoms (such as stuffy nose, cough, sore throat, fever/chills, aches, tiredness) less severe and shortens the recovery time by 1-2 days.
Mechanism of action. Oseltamivir is a neuraminidase inhibitor, a competitive inhibitor of influenza’s neuraminidase enzyme. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir prevents new viral particles from being released. Resistance
Where is the sialic acid found in oseltamivir?
Oseltamivir is a neuraminidase inhibitor, a competitive inhibitor of influenza’s neuraminidase enzyme. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell.
How is oseltamivir similar to neuraminidase in SARS?
Zhang et al. found that the active site of the Spike (S) 1 Protein of SARS is similar to that of neuraminidase, suggesting that neuraminidase inhibitors may be useful to treat SARS-CoV [2]. However, despite this similarity, no clinical data suggest that oseltamivir is effective in treating SARS-CoV.
What is the bioavailability of oseltamivir phosphate?
Oseltamivir is indicated for the treatment and prevention of infections due to influenza A and B viruses. In gastrointestinal tract, there is approximately 80% bioavailability of oseltamivir phosphate, which made it readily absorbed in the cells.