What does Plap mean?
|PLAP||Placental-Like Alkaline Phosphatase|
|PLAP||Provincial Learning Assessment Program (Canada)|
|PLAP||Proposed Local Area Plan (Ireland)|
|PLAP||Platelet to Leukocyte Adhesion Phenomena (hematology)|
What Plap positive?
PLAP is a very sensitive marker for germ cell tumors (positive in > 95% of seminomas) but it lacks specificity. It is frequently expressed in gastrointestinal, gynecologic, breast, lung, and urologic cancers.
Is seminoma cancerous?
A type of cancer that begins in germ cells in males. Germ cells are cells that form sperm in males or eggs in females. Seminomas occur most often in the testicle, but they may also occur in other areas of the body, such as the brain, chest, or abdomen.
What Plap sounds like?
The sound of a plop is abrupt and hollow — you could also call it a plunk or a or a plonk. Plop is imitative or onomatopoeic (it sounds like its meaning), and it first appeared in the 1820s after the brief popularity of the alternative word plap.
What is the shelf life of Plap’s?
|Storage Conditions||Store at 2 to 8 °C, Protect fluorescent conjugates from light, Note: store BSA-free antibodies at -10 to -35 °C|
|Shelf life||Guaranteed for at least 24 months from date of receipt when stored as recommended|
|Regulatory status||For research use only (RUO)|
What is placental alkaline phosphatase test?
Placental alkaline phosphatase (PLAP) is expressed in cytotrophoblasts, syncytiotrophoblasts, and intermediate trophoblast cells. PLAP has been shown to be positive in various tumors, particularly germ-cell tumors and adenocarcinomas.
Is the AFP positive or negative in seminoma?
AFP is negative in seminoma and usually positive in yolk sac tumor; cytokeratin is often negative or weak in seminoma (in routinely processed tissues) whereas it is almost always strongly positive in yolk sac tumor. OCT3/4 and CD117 are strongly positive in seminoma but negative in yolk sac tumor.
What kind of soft tissue is found in seminoma?
Residual soft tissue is frequently seen following chemotherapy or radiation for seminoma. Seminoma often comes into the differential diagnosis of other testicular tumors. Because of the many variations of seminoma morphology, it may be necessary to obtain additional sections to identify a characteristic seminomatous area.
Are there any syncytiotrophoblastic elements in a seminoma?
The syncytiotrophoblastic elements are seen in 10% to 15% of cases, an incidence that corresponds with the incidence of β-human chorionic gonadotropin (β-HCG) elevations in seminomas. Approximately 85% of pure seminomas are of the classic type.
How can you tell the difference between seminoma and EC?
The use of immunohistochemical stains may be useful in distinguishing seminoma from EC. EC cells often stain for CD30 in a membranous pattern, and seminoma cells are usually negative or only very focally positive for this marker.