What does HER2 FISH positive mean?

What does HER2 FISH positive mean?

FISH testing usually returns one of two results: positive or negative. Positive means your breast cancer cells make too much HER2 and your doctor should treat you with drugs that target that protein. Negative means the protein isn’t involved in the growth of your tumor.

What is a fish ratio?

The HER2/CEP17 fluorescence in situ hybridization (FISH) ratio was associated with a pathologic complete response (pCR) with the use of dual anti-HER2 therapy in patients with HER2-positive breast cancer without the use of chemotherapy, suggesting that FISH may be a predictive biomarker of anti-HER2 response, according …

How accurate is a fish test?

FISH is 42-83% sensitive for detecting pTa and pT1 lesions and 92-100% sensitive for pT2-4 invasive lesions in patients with known bladder cancer, while urine cytology yields sensitivities of 24-50% for pTa and pT1 lesions and 78-85% for pT2-4 invasive lesions.

How do I read my FISH test results?

How your doctor interprets this test is as follows:

1. A result of 0 is negative.
2. A result of 1+ is also negative.
3. A result of 2+ is considered equivocal (uncertain).
4. A result of 3+ is positive.

Is HER2-positive or negative Better?

Is HER2-positive breast cancer good or bad? HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast.

What do you need to know about HER2 FISH testing?

What Is HER2 FISH Testing? 1 The human epidermal growth factor receptor 2… 2 Extra HER2 receptors promote the growth of breast cancer. 3 Types of Tests. To determine if your breast cancer is HER2-positive, your doctor will order testing. 4 What to Expect During FISH Testing. To properly diagnose your HER2 status,…

How does a HER2 test work for breast cancer?

The result makes a big difference when it comes to your treatment options and outlook. To determine if your breast cancer is HER2-positive, your doctor will order testing that is conducted on a tissue sample. Two types of tests are approved for HER2 diagnosis: immunohistochemistry (IHC) and in situ hybridization (ISH or FISH).

What do fish test results mean for breast cancer?

These HER2 receptors receive signals that stimulate the growth of breast cancer cells. The FISH test results will tell you that the cancer is either “positive” or “negative” (a result sometimes reported as “zero”) for HER2. Generally, the FISH test is not as widely available as another method of HER2 testing, called ImmunoHistoChemistry, or IHC.

Which is more accurate fish or IHC for breast cancer?

Many breast cancer specialists think that the FISH test is more accurate than IHC. However, it is more expensive and takes longer to get the results. Often the IHC test is done first. If the result is 0 or 1+, the cancer is considered HER2-negative.