What is major groove and minor groove?
The minor groove contains the pyrimidine O-2 and the purine N-3 of the base pair, and the major groove is on the opposite side of the pair. The methyl group of thymine also lies in the major groove. In B-DNA, the major groove is wider (12 versus 6 Å) and deeper (8.5 versus 7.5 Å) than the minor groove (Figure 27.8).
What is the major groove?
Major groove: The wider of the two grooves in a DNA double helix. Related terms: Minor groove, RNA, nucleoside, nucleotide, hydrogen bond, adenine, guanine, cytosine, thymine, secondary structure.
What is the purpose of major and minor grooves?
As you noted, the major groove is wider than the minor groove. These grooves allow proteins to bind to and recognize DNA sequences from the outside of the helix. The grooves expose the edges of each base pair located inside the helix, which allows proteins to chemically recognize specific DNA sequences.
What are DNA grooves?
Two grooves that run the length of the DNA double helix. Each groove is lined by potential hydrogen-bond donor and acceptor atoms, and these interact with DNA-binding proteins that recognize specific DNA sequences.
How do the major and minor grooves in B-DNA compare to those in a DNA?
How do the major and minor grooves in A-DNA compare to those in B-DNA? The major groove in B-DNA is much larger than the minor groove. In A-DNA, both grooves are about the same size.
What is the minor groove?
Minor groove: The narrower of the two grooves in a DNA double helix. Related terms: Major groove, RNA, nucleoside, nucleotide, hydrogen bond, adenine, guanine, cytosine, thymine, secondary structure.
What statement about the major and minor grooves is true?
What statement about the major and minor grooves is TRUE? The major and minor grooves are important for DNA binding proteins to attach to the DNA.
What is the arrangement of major and minor grooves on the same side of a DNA molecule?
Major & Minor Grooves. The major and minor grooves are opposite each other, and each runs continuously along the entire length of the DNA molecule. They arise from the antiparallel arrangement of the two backbone strands.
Why is there a major and minor groove in DNA?
The major and minor (19 kb gif) groove arise because of the orientation of the base pairs across the helix. The grooves separate the two sugar-phosphate backbones from each other and the atoms exposed in the grooves are accessible to the solvent and to interactions with proteins.
Why is there a major groove?
Why is there a major and a minor groove in DNA?
Why are there major and minor grooves in DNA?
DNA Grooves. As the DNA strands are twisted they have distinct grooves. DNA has two kinds of grooves that play important roles in its functioning. Major and minor grooves help in formation of different proteins. These grooves bind proteins like transcription factors that lead to formation of the proteins.
What is a minor groove?
minor groove. A shallow “furrow” in the molecular structure of a DNA double helix, which measures 1.2 nm across and extends the entire length of DNA as long as the molecule remains in a normal or right-handed DNA conformation.
What is the major and minor groove of DNA?
The major groove occurs where the backbones are far apart, the minor groove occurs where they are close together. The grooves twist around the molecule on opposite sides. Certain proteins bind to DNA to alter its structure or to regulate transcription (copying DNA to RNA ) or replication (copying DNA to DNA).