What causes herpesvirus 8?
A type of virus that causes Kaposi sarcoma (a rare cancer in which lesions grow in the skin, lymph nodes, lining of the mouth, nose, and throat, and other tissues of the body). Human herpesvirus 8 also causes certain types of lymphoma (cancer that begins in cells of the immune system).
What diseases does HHV 8 cause?
Recent findings: Diseases caused by HHV-8 infection include Kaposi sarcoma, multicentric Castleman disease (MCD), and primary effusion lymphoma (PEL), which occur primarily in patients with HIV infection. Kaposi sarcoma is the most common AIDS-associated malignancy worldwide.
Is human herpesvirus 8 oncogenic?
From an oncological curiosity described more than 100 years ago to an AIDS-defining cancer, the discovery of Kaposi’s sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) and its oncogenic enigmas has enlightened many fields of tumour biology and viral oncogenesis.
What type of virus is HHV 8?
The Human Herpesvirus-8 (HHV-8), also called Kaposi sarcoma Herpesvirus (KSHV), belongs to the family of DNA viruses Herpeseviridae. It causes Kaposi sarcoma (a vascular malignancy) and B cell lymphoproliferative diseases such as primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD).
What is Hvv 8?
A type of virus that causes Kaposi sarcoma (a rare cancer in which lesions grow in the skin, lymph nodes, lining of the mouth, nose, and throat, and other tissues of the body). HHV8 also causes certain types of lymphoma (cancer that begins in cells of the immune system).
Is HHV and HSV the same?
HSV-1 and HSV-2 are both members of the larger human herpesvirus (HHV) family, which also includes varicella-zoster virus (VZV, or HHV-3) and cytomegalovirus (CMV, or HHV-5). HSV-1, or HHV-1, is the more common cause of adult encephalitis; it is responsible for virtually all cases in persons older than 3 months.
What viruses are oncogenic?
Oncogenic DNA viruses include EBV, hepatitis B virus (HBV), human papillomavirus (HPV), human herpesvirus-8 (HHV-8), and Merkel cell polyomavirus (MCPyV). Oncogenic RNA viruses include, hepatitis C virus (HCV) and human T-cell lymphotropic virus-1 (HTLV-1).
What two main cells would be activated to fight off the human herpesvirus 8?
Extensive evidence indicates that peripheral blood B cells from healthy individuals support productive lytic HHV-8 infection in vitro when activated with CD40L and IL-4, whereas tonsillar B cells do so without requiring ex vivo activation (Rappocciolo et al., 2008).
Is HHV8 RNA or DNA?
What does KSHV stand for?
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is Human gammaherpesvirus 8, or HHV-8 in short. Like other herpesviruses, its informal names are used interchangeably with its formal ICTV name.
Who discovered HHV-8?
HHV-8 was first detected by Chang et al. (56) in Kaposi’s sarcoma (KS) tissues from a patient with AIDS by representational difference analysis. Since its initial discovery, HHV-8 has been found in all forms of KS: classical, endemic, and AIDS-associated iatrogenically acquired KS (265).
What is Oncovirus and carcinogenesis?
Oncoviruses are classified into direct and indirect carcinogens. Direct tumor viruses [HPV, KSHV, HTLV1, EBV (4), and MCPyV (6)] either encode viral oncoproteins or activate host oncoproteins. Indirect viruses (HBV and HCV) however, set the stage for neoplasm mainly by chronic inflammation.