What is beta-2 glycoprotein IgG test?
Beta-2 glycoprotein 1 antibody tests are used along with cardiolipin antibody and lupus anticoagulant testing to help diagnose the cause of an unexplained blood clot (thrombotic episode) or recurrent miscarriages, to help diagnose antiphospholipid syndrome (APS), or to detect the autoantibodies in someone with another …
What is normal range of beta-2 glycoprotein antibodies?
Normal: β2 GPI IgG ≤ 20 SGU U/mL. β2 GPI IgM ≤ 20 SMU U/mL.
What is anti b2gpi antibody test?
Beta 2GP1 Ab. Beta-2 glycoprotein 1 antibodies (IgG, IgM, and very rarely IgA) 28 February 2018. This article waslast modified on 5 August 2021. To help investigate inappropriate blood clot formation; to help determine the cause of recurrent miscarriage; as part of an evaluation for antiphospholipid syndrome (APS)
What causes high beta-2 glycoprotein?
Beta-2 GP1 antibodies are found with increased frequency in patients with systemic rheumatic diseases, especially systemic lupus erythematosus. Beta-2 GP1 antibodies are detected in the clinical laboratory by different types of assays including immunoassays and functional coagulation assays.
What does a positive beta-2 glycoprotein mean?
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
What is anti beta-2 glycoprotein?
Anti-beta-2-glycoproteins (anti-B2GP1 antibodies, anti-beta-2-glycoprotein antibodies) are antibodies produced by an individual’s immune system against his or her own phospholipids. These phospholipids are found on the surface of the platelets responsible for blood clotting (clot formation).
What does a high beta-2 glycoprotein IgM mean?
A high level of beta-2 glycoprotein 1 antibody that is tested and confirmed as positive 12 weeks later means that it is likely that you have APS. This is especially true if other antiphospholipid antibody tests are positive.
What does beta-2-glycoprotein do?
Beta-2-glycoprotein I, also known as apolipoprotein H, inhibits the intrinsic coagulation pathway and is involved in the regulation of blood coagulation. Beta-2-glycoprotein I has been shown to be the primary autoantigen for anti-cardiolipin antibodies.
What is anti beta-2-glycoprotein?
What does a positive beta-2-glycoprotein mean?
What does a positive Anticardiolipin IgM mean?
A positive result means that cardiolipin antibody was detected in the blood. As mentioned earlier, the presence of cardiolipin antibodies may indicate several diseases, such as: Syphilis. Antiphospholipid syndrome (APS) Systemic lupus erythematosus (SLE)
What does Beta 2 glycoprotein 1 IgM mean?
If the blood examination report reveals beta-2 glycoprotein 1 (beta-2 GP1) antibodies more than 40 U/mL for IgM, it points to Antiphospholipid syndrome (APS). Patients that manifest clinical signs of APS can portray reduced levels of beta-2 GP1 antibodies in their blood.
What are beta-2 glycoprotein 1 antibodies for APS?
Strongly positive results for beta-2 glycoprotein 1 (beta-2 GP1) antibodies (>40 U/mL for IgG and/or IgM) are diagnostic criterion for antiphospholipid syndrome (APS). Lesser levels of beta-2 GP1 antibodies and antibodies of the IgA isotype may occur in patients with clinical signs of APS, but the results are not considered diagnostic.
How often can beta 2 GP1 antibodies be detected?
Lesser levels of IgG and IgM beta 2 GP1 antibodies and antibodies of the IgA isotype may occur in patients with clinical signs of APS, but the results are not considered diagnostic. Beta 2 GP1 antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS.
Can a beta-2 GP1 antibody inhibit clot formation?
Antibodies detected using beta-2 GP1 substrate without phospholipid (so called direct assays) are referred to simply as beta-2 GP1 antibodies. Some beta-2 GP1 antibodies are capable of inhibiting clot formation in functional coagulation assays that contain low concentrations of phospholipid cofactors.