What is drug induced hemolytic anemia?
Drug-induced immune hemolytic anemia is a blood disorder that occurs when a medicine triggers the body’s defense (immune) system to attack its own red blood cells. This causes red blood cells to break down earlier than normal, a process called hemolysis.
Can nsaids cause anemia?
Mefenamic acid, ibuprofen, sulindac, naproxen, tolmetin, feprazone, and aspirin are reported to cause IHA, with mefenamic acid most frequently implicated. Mefenamic acid appears to cause hemolytic anemia by an autoimmune mechanism similar to methyldopa and aspirin by an immune complex mechanism.
What causes hemolysis anemia?
Conditions that may lead to hemolytic anemia include inherited blood disorders such as sickle cell disease or thalassemia, autoimmune disorders, bone marrow failure, or infections. Some medicines or side effects to blood transfusions may cause hemolytic anemia.
Can steroids cause hemolysis?
Corticosteroid is an immunosuppressive agent and is very unlikely to cause an autoimmune phenomenon. Therefore, it has been rarely reported as a cause of DIIHA. Hydrocortisone has been shown to induce intracellular hemolysis [5] and hemagglutination [6].
Can taking ibuprofen cause anemia?
Another cause of iron deficiency anemia can be gastrointestinal bleeding, which can be triggered by something as simple as taking too much aspirin or ibuprofen over time.
Does naproxen cause anemia?
But in men and postmenopausal women that type of anemia is almost always due to gastrointestinal bleeding. Such bleeding is often caused by the widespread use of aspirin (yes, even baby aspirin) and nonsteroidal pain relievers such as ibuprofen (Advil, Motrin IB, and generic) and naproxen (Aleve and generic).
Why is dapsone contraindicated in G6PD?
CD was withdrawn from the market in 2008 due to post-licensure hemolytic toxicity in patients with G6PD deficiency; however, dapsone is still used in the prevention and treatment of a variety of diseases [15–17, 36] and can precipitate life-threatening hemolysis in individuals with G6PD deficiency.
What is the mechanism of action of dapsone?
As an antimicrobial agent, dapsone is bacteriostatic in action. It inhibits the synthesis of dihydrofolic acid through by competing with para-aminobenzoic acid for the active site of dihydropteroate synthetase [35, 41], thus resembling the action of sulphonamides.
How does Hypersplenism cause anemia?
When your spleen’s overactive, or “hyper,” it removes too many blood cells, including healthy ones. Without enough healthy, mature blood cells, your body has a harder time fighting infections and you may become anemic.
What does it mean to have inherited hemolytic anemia?
Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than they are made. Inherited hemolytic anemia means that parents pass the gene for the condition on to their children. Acquired hemolytic anemia is not something you are born with. You develop the condition later.
What are the non specific signs of haemolytic anaemia?
If intravascular haemolysis predominates, the patient may complain of back pain and dark urine due to haemoglobinuria. On examination, there may be non-specific signs of anaemia including: High-output cardiac failure: occurs rarely in severe anaemia.
When to do a peripheral blood smear for hemolytic anemia?
A peripheral blood smear should be performed when hemolysis is present to identify abnormal red blood cell morphologies. Hemolytic diseases are classified into hemoglobinopathies, membranopathies, enzymopathies, immune-mediated anemias, and extrinsic nonimmune causes.
Where are the red cells destroyed in haemolytic anaemia?
In haemolytic anaemia red cells are destroyed prematurely, either within the circulation (intravascular haemolysis) or within the reticuloendothelial system (extravascular haemolysis).