What does AUC 5 mean?

What does AUC 5 mean?

For a target AUC = 5, the maximum dose is 5 x 150 = 750 mg. For a target AUC = 4, the maximum dose is 4 x 150 = 600 mg.

How do you calculate carboplatin?

Carboplatin Dose (mg) = Target area under the curve (AUC mg/mL/min) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).

How is target AUC calculated?

This formula can be used to calculate the carboplatin dose accurately in order to obtain a target AUC by using only the GFR. The formula is: dose (mg) = AUC (mg ml-1 min) x [GFR (ml/min) + 25 (ml/min)].

Is GFR the same as creatinine clearance?

Creatinine clearance ( CrCl ) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus).

What is AUC chemo?

AUC is the “area under the curve” – a figure that reflects the concentration of drug in the body that doctors want to achieve; GFR is the glomerular filtration rate – the rate at which an individual patient’s kidneys work; A is the ratio of this glomerular filtration rate to how quickly the kidneys get rid of …

How do you calculate GFR from carboplatin?

Because carboplatin clearance depends largely on GFR, the dose of carboplatin needed to achieve a target AUC has historically been calculated starting with an assessment of GFR (Figure), using the Calvert formula: Dose (mg) = target AUC ((mg/mL)•min) × (GFR + 25) (mL/min)6, where the constant of 25 mL/min represents …

Which is more important creatinine or GFR?

Because the “good” creatinine number is different in different people, GFR is more accurate in finding out if your kidneys are ok. Your GFR will help determine your stage of kidney disease. GFR and creatinine are usually measured and reported together.