How do you synthesize Acetanilide?

How do you synthesize Acetanilide?

Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.

What is synthesis of Acetanilide?

Acetanilide is synthesized from aniline by acetylating it with acetic anhydride in presence of glacial acetic acid. Aniline or phenylamine is a primary amine and basic in nature. Aniline reacts with acetic anhydride to form Acetanilide by nucleophilic substitution reaction and the reaction is called acetylation.

What is the formula of Acetanilide?

C8H9NO
Acetanilide/Formula

What type of reaction is acetylation?

Acetylation is a chemical reaction that is called ethanoylation in the IUPAC nomenclature. It describes a reaction that introduces an acetyl functional group into a chemical compound. The opposite chemical reaction is called deacetylation – it is the removal of the acetyl group.

What is the molecular formula of aniline?

C6H5NH2
Aniline/Formula

What type of reaction is the bromination of acetanilide?

The bromination of acetanilide is an electrophilic substitution reaction in which the double bond of the para carbon of the acetanilide attacks on the electrophile (bromine atom), thereby forming a carbocation.

How do you calculate acetanilide yield?

PROCEDURE

1. 10 g of aniline shall yield acetanilide = 135.16 / 93 × 10 = 14.5 g.
2. Then, Percentage Practical yield = Practical yield / Theoretical yield × 100.
3. = 12 / 14.5 × 100 = 82.75 %

Which is the derivative of acetanilide?

Para red is considered a derivative of acetanilide, simply because it’s ‘derived’ from the compound as a building block. Another important derivative of acetanilide is a molecule called sulfanilamide.

What is Iupac name of acetanilide?

N-phenylacetamide
N-phenylethanamide
Acetanilide/IUPAC ID

What is acetylation explain acetylation of salicylic acid with equation?

Acetylation is a chemical reaction in which a hydrogen atom is substituted for an acetyl group (CH3C=O. When the hydrogen atom belonging to an alcohol group replaced with an acetyl group in an acetylation reaction, an ester is formed as the product.

How do you Deacetylate chitin?

The method is quite simple:

1. prepare a 50% NaOH aqueous solution (1 lit)
2. Add to above solution about 40-50 gr chitin and raise temperature to about 90C.
3. Continue the deacetylation reaction for 24 hours.
4. filter the suspension mixture and wash the prepared chitosan with water untill you reach the neutral pH.

What is the molar mass of Acetanilide?

135.17 g/mol
Acetanilide/Molar mass

How does the synthesis of acetanilide take place?

Synthesis of Acetanilide was started from aniline and acetic anhydride via a nucleophilic acyl substitution reaction to form acetanilide and acetid acid under water (base).Under a basic condition, the free electrons in amine (aniline) attracts the C2 of Acetic anhydride (carbonyl group of acyl compound) and formed tetrahedral intermediate.

How to make acetanilide from glacial acetic acid?

It is an antipyretic agent. Add 20 ml of a mixture of acetic anhydride and glacial acetic acid (equal volumes) to 10 ml (10.3 g) of aniline in a conical flask of 250 ml. Fit a reflux water-condenser to the flask and gently boil the mixture for 10 min. Then pour the hot liquid into 200 ml of cold water with constant stirring.

How is acetanilide prepared as a febrifuge?

Acetanilide is medicinally important and it is used as febrifuge. Acetanilide cal also be prepared by acetylating aniline with acetic anhydride in the presence of concentrated hydrochloric acid. Dissolve aniline in hydrochloric acid and add acetic anhydride stir well. Pour the mixture to sodium acetate in water.

How is the theoretical yield of acetanilide calculated?

So the theoretical yield of acetanilide is 0.160g. If the student had a perfect lab day he or she would collect 0.160g and have a 100%.percent yield. But the student only collected 0.132g of acetanilide. To get the percent yield, we calculate 0.132g as a percent of 0.160g: