What is the function of histone methylation?
Histone methylation plays an important role on the assembly of the heterochromatin mechanism and the maintenance of gene boundaries between genes that are transcribed and those that aren’t. These changes are passed down to progeny and can be affected by the environment that the cells are subject to.
What is H3K4 methylation?
H3K4 methyltransferases. H3K4 methylation is an evolutionarily conserved histone modification that marks active transcription and is highly enriched at the promoter region and transcription start site. H3K4 methyltransferases are highly conserved from yeast to human.
What is H3K4me3 a marker of?
H3K4 trimethylation (H3K4me3) is a critical marker of active transcription, enhancer signatures, and developmentally stable genes9,10.
How is H3K36 methylation related to gene repression?
While H3K36me deposited by SET-2 marks active genes, inactive genes are modified by ASH1 and its activity is critical for their repression. ASH1-marked chromatin can be further modified by methylation of H3K27, and ASH1 catalytic activity modulates the accumulation of H3K27me2/3 both positively and negatively.
Can a mutation in H3K36 cause glioblastoma?
The direct or indirect disruption of H3K36me by mutation of histone H3 genes defines distinct subtypes of pediatric chondroblastoma (H3.3K36M) and glioblastoma (H3.3G34R/V) ( Fang et al., 2016; Lu et al., 2016; Schwartzentruber et al., 2012 ).
How does methylation of H3K27 affect Ash1 function?
ASH1-marked chromatin can be further modified by methylation of H3K27, and ASH1 catalytic activity modulates the accumulation of H3K27me2/3 both positively and negatively. These findings provide new insight into ASH1 function, H3K27me2/3 establishment, and repression in facultative heterochromatin.
Can a H3K36me3 be on the same histone tail?
Cohabitation of H3K36me3 with either H3K27me2/3 or H3K9me2/3 on the same histone tail is rare ( Jamieson et al., 2016; Voigt et al., 2012; Young et al., 2009 ), and deposition of one mark can inhibit deposition of the second ( Schmitges et al., 2011; Voigt et al., 2012; Yuan et al., 2011 ).