What is sodium valproate used for?
Sodium valproate is used to treat epilepsy and bipolar disorder. It’s occasionally used to prevent migraine headaches. This medicine is only available on prescription. It comes as capsules, tablets and a liquid that you swallow.
What class of drug is sodium valproate?
Acid
Short-chain fatty acid
Sodium valproate/Classification
Sodium valproate or valproic acid is from a group of medications called anti- epileptics or anti-convulsants. It is only available with a doctor’s prescription. WHAT IS IT FOR? It is used to control seizures (fits) in most types of epilepsy.
What drugs should not be taken with sodium valproate?
Some products that may interact with this drug include: certain antidepressants (e.g., amitriptyline, nortriptyline, phenelzine), certain antibiotics (carbapenems such as doripenem, imipenem), irinotecan, mefloquine, orlistat, other medications for seizure (e.g., ethosuximide, lamotrigine, phenytoin, rufinamide.
What are the contraindications of sodium valproate?
Contraindications : Contraindicated in patients with known hypersensitivity to the drug, in patients with known urea cycle disorders, in active liver disease and family history of liver dysfunction, and in porphyria.
Does sodium valproate affect sperm?
Valproate therapy can result in reduced sperm count, motility and abnormal morphology. Valproate’s adverse effects on male fertility are reversible in some patients. Abnormalities may be dependent on the dose and the duration of Valproate treatment.
How is sodium valproate excreted?
Less than 3% of an administered dose of valproate is excreted unchanged (i.e., as valproate) in urine. Only a small amount is excreted via the faeces. Elimination half-life is 16±3 hours and can decrease to 4–9 hours when combined with enzyme inducers.
What is the other name for sodium valproate?
Valproate
| Clinical data | |
|---|---|
| Trade names | Depakote, Epilim, Convulex, others |
| Other names | Valproic acid; Sodium valproate (sodium); Valproate semisodium (semisodium); 2-Propylvaleric acid |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682412 |
What is Epilizine used for?
Epilizine® is an international brand name for sodium valproate or valproate sodium, the sodium salt of valproic acid. This agent is an anticonvulsant used in the treatment of epilepsy and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer.
What does sodium valproate do to the brain?
Sodium valproate prevents epileptic fits by stabilising excessive electrical activity in the brain. It is thought to achieve this in two ways: by increasing the activity of a natural ‘nerve-calming’ agent called GABA in the brain, and by preventing electrical signals from building up in nerve cells in the brain.
How is sodium valproate given?
Sodium valproate injection may be given by direct slow intravenous injection or by infusion using a separate intravenous line in normal saline, dextrose 5%, or dextrose saline. Dosage requirements vary according to age and body weight. Each vial of sodium valproate injection is for single dose injection only.
What is the mechanism of action of valproate?
Valproate is known to inhibit succinic semialdehyde dehydrogenase. This inhibition results in an increase in succinic semialdehyde which acts as an inhibitor of GABA transaminase ultimately reducing GABA metabolism and increasing GABAergic neurotransmission.
Can I marry a boy with epilepsy?
There is no reason why an epileptic person cannot get married and have children and lead a normal life. However, correct diagnosis is required as there are several kinds of epileptic seizures. Proper medication and precautions need to be taken though.