What is a tolerogenic response?
Tolerogenic therapy aims to induce immune tolerance where there is pathological or undesirable activation of the normal immune response. Research using animal models in transplantation and autoimmune diseases has led to early-phase human trials of tolerogenic therapy for autoimmune conditions like Type 1 Diabetes.
How do tolerogenic vaccines work?
As opposed to conventional immunogenic vaccines that are preventative and drive humoral immunity, tolerogenic vaccines exhibit therapeutic action by reversing pre-established autoimmune disease via the direct inactivation of pre-existing pathogenic effector/ memory T cells together with induction and/or expansion of …
What is tolerogenic phenotype?
Tolerogenic DCs often display an immature or semi-mature phenotype with characteristically low expression of costimulatory (e.g. CD80, CD86) and MHC molecules on their surface. Human tolerogenic DCs may be induced by various immunosuppressive drugs or biomediators.
What are tolerogenic vaccines used for?
Tolerogenic vaccines represent a new class of vaccine designed to re-establish immunological tolerance, restore immune homeostasis, and thereby reverse autoimmune disease.
What is meant by tolerogenic?
Medical Definition of tolerogenic : capable of producing immunological tolerance tolerogenic antigens.
What is tolerogenic cell death?
The tolerogenic effect of cell death depends on many factors, including the absence of T cell help, the location of the dying cells (which in part dictates their engulfment by distinct dendritic cell (DC) subtypes), the maturation state of the DC, the production of immunosuppressive factors (such as transforming growth …
What is high zone tolerance?
The relative success of liver transplantation may be explained by high zone tolerance (high and low zone tolerance is the phenomenon that the immune system reacts only if the antigen number is neither too large nor too small) since this organ is large and quick to regenerate.
What is Tolerogen in immunology?
Definition. A foreign antigen that suppresses immune response, or produces immune tolerance. Supplement. In comparison with immunogen that induces an immune response, a tolerogen evokes immune tolerance.
What is Immunogenetics genetics?
Definition. Immunogenetics is the study of the genetic basis of the immune response. It includes the study of normal immunological pathways and the identification of genetic variations that result in immune defects, which may result in the identification of new therapeutic targets for immune diseases.
What is immunocompetent patient?
Scientifically, to be immunocompetent simply means that the immune system is working properly and that the body is capable of mounting an appropriate immune response, when necessary.
What are immune complex diseases?
Immune complex diseases encompass a diverse group of inflammatory conditions characterised by antigen–antibody deposition and attendant activation of complement. Common manifestations include glomerulonephritis, synovitis and dermal vasculitis. Many patients present with constitutional symptoms and less specific signs.