What does Sox10 stain?
Sox10 also marks normal myoepithelial cells of salivary gland and bronchial and mammary ducts and lobules, and it stains the myoepithelial component of salivary gland neoplasms such as myoepithelioma or pleomorphic adenoma. Sox10 labels both benign melanocytes (nevus cells) and the vast majority of melanomas.
What does Sox10 negative mean?
The sensitivity and specificity for SOX10 in the diagnosis of melanoma are 1.0 and 0.93, respectively; the positive and negative predictive values are 0.87 and 1.0, respectively. SOX10 is a sensitive, specific marker for melanoma.
Is neurofibroma Sox10 positive?
In summary, Sox10 shows an increased specificity for tumors of neural crest origin compared with S100: Sox10 was positive in only 5 of 668 cases (99% specificity) in nonschwannian, nonmelanocytic tumors, whereas S100 was positive in 53 of 668 cases (91% specificity).
Are schwannomas Sox10 positive?
The numbers in parentheses include expression in entrapped Schwann cells. PNST = peripheral nerve sheath tumor. All 47 S100 protein-positive granular cell tumors were Sox10-positive, whereas all 6 S100 protein-negative non-neural granular cell tumors, including 2 oral lesions in infants, were negative.
Is SOX 10 a nuclear stain?
SOX10 is a nuclear transcription factor that plays an important role in schwannian and melanocytic cell differentiation, and has been shown to be a useful marker in the diagnosis of melanocytic and schwannian tumors.
What does Melan A positive mean?
The presence of Melan-A positive dermal cells in excisions for melanoma in situ represents a frequent conundrum for pathologists. These cells may represent superficially invasive melanoma, benign, incidental, dermal nevi or non-specific staining of dermal melanophages.
What is Sox 10 a marker for?
SOX10 (Sry-related HMg-Box gene 10) is a key nuclear transcription factor in the differentiation of neural crest progenitor cells to melanocytes. It has been shown to be a sensitive and specific marker of malignant melanoma of multiple histologic types.
What is clear cell sarcoma?
Clear cell sarcoma, or CCS, is a type of cancer called soft tissue sarcoma. CCS tumors occur most often in the arms, legs, feet, and hands. But, CCS can grow throughout the torso, including the stomach and intestines. CCS has also been found in the genitals and head.
What is a Neurilemmoma?
A neurilemmoma, also known as schwannoma, neurolemmoma, and peripheral fibroblastoma, is a benign, encapsulated neoplasm derived from Schwann cells. Along with neurofibroma, schwannoma constitutes one of the two most common benign peripheral nerve sheath tumors.
What is malignant schwannoma?
It is a type of peripheral nerve sheath tumour that is cancerous (malignant). Most peripheral nerve sheath tumours are not cancerous (benign). A tumour is a lump or growth in the body. One type of non cancerous peripheral nerve sheath tumour is called a schwannoma.
What is the difference between neurofibroma and schwannoma?
Neurofibromas are benign, heterogeneous peripheral nerve sheath tumours arising from the connective tissue of peripheral nerve sheaths, especially the endoneurium. Schwannomas are benign encapsulated tumours originating from the Schwann cells of the peripheral nervous system.
Is a compound nevus benign or malignant?
Compound naevi are considered to be benign neoplasms of melanocytes if they arise in later life. Compound naevi arise from a flat (junctional) naevus that exists earlier in life and may have a raised central portion of deeper pigmentation with surrounding tan-brown macular pigmentation.
Where does SOX10 occur in the developing cell?
SOX10 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. During development, SOX10 first appears in the forming neural crest and continues to be expressed in Schwann cells.
Where is SOX10 found in a Schwann cell?
SOX10 (EP268) Rabbit Monoclonal Antibody. SOX10 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. During development, SOX10 first appears in the forming neural crest and continues to be expressed in Schwann cells.
What kind of tumors are SOX10 antibodies expressed in?
It is also an important marker in malignant tumors such as melanoma, breast carcinoma, gliomas and benign tumors such as schwannomas. SOX10 antibody has been shown to be expressed in 97-100% of desmoplastic and spindle cell melanomas and was also shown to be expressed in 100% of nevi.