Which neuromuscular blocking agent is a Benzylisoquinoline compound?
Recent findings: The benzylisoquinoline compound gantacurium is a nondepolarizing muscle relaxant with an ultrashort duration largely determined by the rapid rate at which endogenous L-cysteine binds to, and permanently inactivates, the molecule.
Which drug is used as a neuromuscular blocking agents?
Neuromuscular blocking agents (NMBAs) come in two forms: depolarizing neuromuscular blocking agents (e.g., succinylcholine) and nondepolarizing neuromuscular blocking agents (e.g., rocuronium, vecuronium, atracurium, cisatracurium, mivacurium).
What are Curariform drugs?
Muscle relaxants, which obey these criteria and therefore interfere at the neuro- muscular junction are called curariform drugs irrespective of whether or not their mechanism of action is identical with that of curare.
Which of the following drug is Nondepolarizing muscle relaxant?
Metocurine is a muscle relaxant….Neuromuscular-Blocking Agents (Nondepolarizing)
| Drug | Target | Type |
|---|---|---|
| Metocurine | Muscarinic acetylcholine receptor M2 | target |
| Pancuronium | Neuronal acetylcholine receptor subunit alpha-2 | target |
| Pancuronium | Cholinesterase | enzyme |
| Pancuronium | Muscarinic acetylcholine receptor M2 | target |
Can you reverse succinylcholine?
Sugammadex can reverse profound blockade and can be given for immediate reversal and its use would avoid the potentially serious adverse effects of the currently used agent, succinylcholine. Also, sugammadex can reverse NMB more quickly and predictably than existing agents.
Is propofol a neuromuscular blocker?
Propofol is a widely used drug in anesthesia practice, and its pharmacological characteristics are well known. However, propofol is not known for neuromuscular effects.
Is succinylcholine a neuromuscular blocking agent?
The most well-known depolarizing neuromuscular blocking agent is succinylcholine. It is the only such drug used clinically and is considered by many the drug of choice for emergency department RSI, although this is controversial.
What do neuromuscular blocking agents do?
Neuromuscular blocking agents are among the most commonly used drugs during general anesthesia. They compete with acetylcholine and interfere with the transmission of nerve impulses resulting in skeletal muscle relaxation.
Why is decamethonium not used clinically?
In clinical use, the reliability of action of decamethonium makes an antidote unnecessary, but should a prolonged action occur, then it is likely that this may be due to a dual block, and it would be logical to observe the effect of a small dose of an anticurare drug.
Is bupivacaine a neuromuscular blocking agent?
At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade.
What is the difference between succinylcholine and rocuronium?
Succinylcholine’s duration of action is 10—15 minutes, whereas the half-life of rocuronium is anywhere from 30—90 minutes, depending on the dose. However, succinylcholine has major side effects, including hyperkalemia, malignant hyperthermia, fasciculations and bradycardia.