What is fusilev used for?
Fusilev (levoleucovorin) is a derivative of folic acid indicated for the treatment of metastatic colorectal cancer and bone cancer (after methotrexate therapy).
Is levoleucovorin the same as leucovorin?
Levoleucovorin can be used interchangeably with leucovorin for modulating fluorouracil.
How do you reconstitute leucovorin?
Reconstitute the lyophilized vial products with Bacteriostatic Water for Injection, USP (benzyl alcohol preserved), or Sterile Water for Injection, USP. When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days.
What is Levoleucovorin used for?
Levoleucovorin injection is used in adults and children to prevent harmful effects of methotrexate (Trexall) when methotrexate is used to treat osteosarcoma (cancer that forms in bones).
Who makes oxaliplatin?
The sanofi-aventis Group announced today that it has received marketing approval from the United States Food and Drug Administration for a new aqueous solution formulation of ELOXATIN™ (oxaliplatin injection).
What is leucovorin prescribed for?
Leucovorin is used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of folic acid in the body. This includes methotrexate (Rheumatrex), pyrimethamine (Daraprim), trimethoprim (Trimpex, Proloprim), and others.
Does leucovorin cause hair loss?
This action also effects normal cells which can cause significant side effects in the body, such as: low white, red and platelet blood cell counts, hair loss, mouth sores, difficulty swallowing, diarrhea, liver, lung, nerve and kidney damage.
When should leucovorin be administered?
Leucovorin is normally started 24 hours after methotrexate is given. This delay gives the methotrexate a chance to exert its anti-cancer effects. Leucovorin is also used by itself to treat certain anemia problems when folic acid deficiency is present.
Can leucovorin be given IV push?
There is 0.004 mEq of calcium per mg of leucovorin. Solution contains no bacteriostat or antimicrobial agents. Leucovorin Calcium for Injection is a sterile product indicated for intramuscular (IM) or intravenous (IV) administration and is supplied in 50 mg, 100 mg, 200 mg, and 350 mg vials.
Is Levoleucovorin chemo?
LEVOLEUCOVORIN (LEE voe LOO koe VOE rin) is used to prevent or treat the harmful effects of some chemotherapy medicines like methotrexate. It is also used with 5-fluorouracil (5-FU) to treat colon cancer.
Which is the best dosage of Fusilev to take?
Fusilev is indicated for intravenous administration only. Do not administer intrathecally. The recommended dosage for Fusilev is based on a methotrexate dose of 12 grams/m 2 administered by intravenous infusion over 4 hours.
When to use Fusilev after methotrexate therapy?
• Fusilev™ is a folate analog. • Fusilev rescue is indicated after high-dose methotrexate therapy in osteosarcoma. • Fusilev is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosage of folic acid antagonists. 1.1 Limitations of Use Fusilev
When is the best time to start Fusilev?
Start Fusilev as soon as possible after an overdosage of methotrexate or within 24 hours of methotrexate administration when methotrexate elimination is impaired. As the time interval between methotrexate administration and Fusilev increases, the effectiveness of Fusilev to diminish methotrexate toxicity may decrease.
How is Fusilev used to treat colorectal cancer?
Fusilev Administration in Combination with 5-Fluorouracil (5-FU) The following regimens have been used historically for the treatment of colorectal cancer: Fusilev is administered at 100 mg/m2 by slow intravenous injection over a minimum of 3 minutes, followed by 5-FU at 370 mg/m2 by intravenous injection.