What is trovafloxacin used for?
Trovafloxacin is an antibiotic in the class of drugs called fluoroquinolones. It fights bacteria in the body. Trovafloxacin is used to treat serious infections including pneumonia, complicated abdominal infections, gynecologic and pelvic infections, and skin infections.
Why was Trovan taken off the market?
Trovafloxacin was approved by the FDA in 1997. Pfizer withdrew Trovan from Markets worldwide in 2001 because of the risk of fatal liver failure.
What drug is a fluoroquinolone?
Fluoroquinolones are a class of antibiotics approved to treat or prevent certain bacterial infections. The fluoroquinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), and ofloxacin (Floxin).
Is Trovan safe?
Trovan® HAS BEEN ASSOCIATED WITH SERIOUS LIVER INJURY LEADING TO LIVER TRANSPLANTATION AND/OR DEATH. Trovan-ASSOCIATED LIVER INJURY HAS BEEN REPORTED WITH BOTH SHORT-TERM AND LONG-TERM DRUG EXPOSURE. Trovan USE EXCEEDING 2 WEEKS IN DURATION IS ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF SERIOUS LIVER INJURY.
Why was trovafloxacin was withdrawn from market?
Trovafloxacin (sold as Trovan by Pfizer and Turvel by Laboratorios Almirall) is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity.
Can amikacin be given orally?
Amikacin may be administered once or twice a day and is usually given by the intravenous or intramuscular route, though it can be given via nebulization. There is no oral form available, as amikacin is not absorbed orally.
When should you take Prempro?
PREMPRO therapy consists of a single tablet to be taken orally once daily. PREMPHASE therapy consists of two separate tablets: one maroon 0.625 mg CE tablet taken daily on days 1 through 14 and one light-blue tablet containing 0.625 mg CE and 5 mg MPA taken on days 15 through 28.
What is the generic name for Clozaril?
It is also used to help reduce the risk of suicidal behavior in people with schizophrenia or similar disorders. Clozapine is available under the following different brand names: Clozaril, FazaClo ODT, and Versacloz.
Is amoxicillin a fluoroquinolone drug?
Levaquin belongs to the fluoroquinolone class of antibiotics, while amoxicillin is a penicillin type of antibiotic. Both Levaquin and amoxicillin are used to treat infections of the lungs, airways, skin, urinary tract, and ears. Differences between the two drugs include the conditions the drugs are used to treat.
Was Levaquin discontinued?
Janssen pharmaceutical companies of Johnson & Johnson discontinued production of Levaquin in December 2017, including the oral and IV versions. However, Levaquin may still be available in pharmacies until 2020.
Who made Trovan?
A secret Nigerian government report concluded that the drug manufacturer Pfizer undertook an “illegal trial of an unregistered drug” when the company enrolled nearly 100 Nigerian children with meningitis in a trial testing its antibiotic trovafloxacin (Trovan) against ceftriaxone during a 1996 meningitis epidemic.
What class of antibiotic is nalidixic acid?
Neggram is a prescription medicine used to treat the symptoms of Urinary Tract Infections. Neggram may be used alone or with other medications. Neggram belongs to a class of drugs called Quinolone Antibiotics.
How does trovafloxacin work as an antibiotic?
Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV.
Who is the manufacturer of trovafloxacin brand name?
Trovafloxacin is sold under the brand name Trovan®, manufactured by Pfizer. The sections below will provide you with more specific information and guidelines related to trovafloxacin and its correct use. Please read them carefully.
Is it safe to take trovafloxacin while pregnant?
Trovafloxacin is in the FDA pregnancy category C. This means that it is not known whether trovafloxacin will be harmful to an unborn baby. Do not take trovafloxacin without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Who was the lead investigator in the trovafloxacin case?
The case came to light in December 2000 as the result of an investigation by The Washington Post, and sparked significant public outcry. The most serious error was the falsification and backdating of an ethics approval letter by the lead investigator of the trial, Dr. Abdulhamid Isa Dutse.