Does vincristine cause ototoxicity?
Other chemotherapy drugs that can cause ototoxicity are Bleomycin, Vincristine, Vinblastin, Bromocriptine, and Methotrexate Nitrogen Mustard.
Does doxorubicin cause ototoxicity?
Although doxorubicin [adriamycin (ADM)] ototoxicity has not been detected to date, it has been reported that neurotoxicity in the central nervous system was induced by chemotherapy with ADM in patients receiving chronic cyclosporin A (CsA) treatment.
How is cisplatin Ototoxic?
Dose-related ototoxicity is illustrated by the report that 20% of patients treated with cisplatin for testicular cancer experience permanent ototoxicity, but > 50% of patients who received cisplatin in doses > 400 mg/m2 cumulative dose had permanent hearing loss (Bokemeyer et al. 1998).
What is the mechanism of platinum compounds in ototoxicity?
Platinum ototoxicity is due to the degeneration of mechanosensory hair cells in the organ of Corti, the spiral ganglion, and the lateral wall cells (stria vascularis and spiral ligament) [30].
Which anticancer drugs cause ototoxicity?
Two major classes of such “ototoxic” drugs are the aminoglycoside antibiotics and the anti-cancer drug cisplatin. These drugs save lives, but can also result in permanent hearing loss.
How does chemotherapy cause ototoxicity?
About half of all chemotherapy patients are treated with a drug made with platinum, a heavy metal, they may damage the myelin sheath, the plasma membrane that forms around the nerves and protects them. The drugs also may affect the fine nerve endings inside the ears.
Which of the following anticancer drugs cause ototoxicity?
Chemotherapeutic (antineoplastic) drugs, particularly those containing platinum (cisplatin and carboplatin), can cause tinnitus and hearing loss.
Which drug reported during a health history should concern most about ototoxicity?
Ototoxicity came to the forefront of clinical attention with the discovery of streptomycin in 1944. Streptomycin was used successfully in the treatment of tuberculosis; however, a substantial number of treated patients were found to develop irreversible cochlear and vestibular dysfunction.
Why does cisplatin cause ototoxicity?
The molecular mechanisms of cisplatin ototoxicity therefore include the following:(i)“Creation of reactive oxygen species,(ii)Depletion of antioxidant glutathione and its regenerating enzymes,(iii)Increased rate of lipid peroxidation,(iv)Oxidative modifications of proteins,(v)Nucleic acids damage by caspase system …
Why does cisplatin cause nephrotoxicity?
Cisplatin nephrotoxicity is the composite result of the transport of cisplatin into renal epithelial cells, injury to nuclear and mitochondrial DNA, activation of a multiple cell death and survival pathways and initiation of a robust inflammatory response.
Is furosemide ototoxic?
Furosemide is an ototoxic diuretic. Furosemide injection is followed by a rapid, but reversible decrease of the endocochlear potential and eighth nerve action potential with a more gradual decrease of the endolymph potassium concentration.
Is neomycin an ototoxic?
Neomycin is very toxic to the hearing part of the inner ear. Some of the solvents for the antibiotics have also been reported as being ototoxic. Propylene glycol is an example (Morizono et al, 1980). As you can see below, numerous commonly used ear preparations contain these drugs.