What is the classification of metolazone?

What is the classification of metolazone?

Metolazone is in a class of medications called diuretics (‘water pills’). It causes the kidneys to reduce the amount of water and salt in the body by increasing the amount of urine.

What type of diuretic is metolazone?

Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure . This medicine is available only with your doctor’s prescription .

What classification is Lotensin?

Lotensin is a prescription medicine used to treat the symptoms of High Blood Pressure (Hypertension). Lotensin may be used alone or with other medications. Lotensin belongs to a class of drugs called ACE Inhibitors.

What is the indication for metolazone?

Metolazone tablets are indicated for the treatment of salt and water retention including: edema accompanying congestive heart failure; edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.

Why are diuretics given in a clinical setting?

Diuretics are used effectively in the management of hypertension, and are typically prescribed because of their efficacy, low cost, and low side effects profile. Diuretics are known for their ability to increase the formation and excretion of urine.

What class of diuretics does acting on the proximal tubule?

Diuretics that work primarily in the proximal tubule include osmotic diuretics (e.g., mannitol), diuretics that interfere with the adenyl cyclase system (e.g., xanthines), and those which inhibit carbonic anhydrase (e.g., acetazolamide).

What kind of diuretic is spironolactone?

Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

What is metolazone mechanism of action?

Mechanism of Action Metolazone works by inhibiting sodium transport across the epithelium of the renal tubules (mostly in the distal tubules), resulting in a decrease in sodium reabsorption and an increase in sodium, chloride, and water excretion.

What class of drug is benazepril hydrochloride?

Benazepril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly.

What is benazepril 20 mg used for?

Benazepril is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries.

Why is metolazone given before furosemide?

Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function.

When thiazide and loop diuretics are administered the patient should be monitored for?

After oral use, diuresis begins within 2 hours, peaks in about 4 hours, and lasts about 6 to 12 hours. Use with caution in severe renal disease. Patients who are taking thiazide diuretics should be monitored for electrolyte depletion, dehydration, weakness, hypotension, renal impairment, and hypersensitivities.

What do you need to know about metolazone?

Metolazone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metolazone is used to treat fluid retention ( edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome.

How is metolazone used in chronic renal failure?

It is a quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. [PubChem]The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption.

Can you take Metolazone and furosemide at the same time?

Metolazone tablets, USP, and furosemide administered concurrently have produced marked diuresis in some patients where edema or ascites was refractory to treatment with maximum recommended doses of these or other diuretics administered alone. The mechanism of this interaction is unknown (see WARNINGS and PRECAUTIONS, Drug Interactions ).

How does metolazone work on the DCT?

Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water.

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