What is the major function of a Src homology 3 SH3 domain?
Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications.
What is SH2 and SH3 domains?
SH2 and SH3 domains are small protein modules that mediate protein-protein interactions in signal transduction pathways that are activated by protein tyrosine kinases. SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids.
What is SH3 domain binding?
The SH3 domain is a distinct motif that binds target proteins, including proteins associated with the actin cytoskeleton, through sequences containing proline and hydrophobic amino acids.
Which intracellular proteins contain SH2 domains?
The SH2 domain-containing phosphatases (Shps) belong to a class of non-transmembrane protein tyrosine phosphatases that contain two N-terminal SH2 domains. There are two vertebrate Shps: SHP1 and SHP2.
What does SH3 stand for?
SH3
| Acronym | Definition |
|---|---|
| SH3 | Src (Sarcoma) Homology 3 Domain |
| SH3 | Silent Hill 3 (game) |
| SH3 | Ship’s Serviceman Third Class (Naval Rating) |
What does the PH domain do?
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways.
What is GRB2 and SOS?
Grb2 protein, which is the downstream effector of the EGF receptor, acts as an adaptor protein between the EGF receptor and the Ras guanine-nucleotide exchange factor, son of sevenless (Sos) protein. Sos protein regulates the action of Ras protein by promoting the exchange of GDP for GTP.
What role do the Sh2 and Sh3 domains play in the function of GRB2?
What role do Sh2 and Sh3 domains play in the function of GRB2? GRB2 is an adaptor protein. It contains one Sh2 domain, and two Sh3 domains on the N terminal and C terminal ends. Sh3 directs the binding of proline rich proteins of other compounds, and Sh2 directs the binding of tyrosine phosphorylated sequences.
What does PDZ domain stand for?
PDZ is an initialism combining the first letters of the first three proteins discovered to share the domain — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1). …
Which protein contains an SH2 Src homology 2 domain and what does it bind to?
The structure consists of a large beta sheet (green) flanked by two alpha-helices (orange and blue). The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.
What is the function of the SH2 domain in SRC?
Src homology 2 (SH2) domains are protein modules (of approximately 100 amino acids) found in many proteins involved in tyrosine kinase signalling cascades. Their function is to bind tyrosine-phosphorylated sequences in specific protein targets.
Which of the following proteins contains an SH3 domain?
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk….
| SH3 domain | |
|---|---|
| Pfam | PF00018 |
| Pfam clan | CL0010 |
| InterPro | IPR001452 |
| SMART | SM00326 |
How many amino acids are in the Src homology 3 domain?
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.
Which is Src homology 3 ( SH3 ) domain bind PXXP?
? Src Homology 3 (SH3) domains are protein interaction domains that bind proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. Thus, they are referred to as proline-recognition domains (PRDs).
How are SH3 domains different from other PRDS?
Thus, they are referred to as proline-recognition domains (PRDs). SH3 domains are less selective and show more diverse specificity compared to other PRDs. They have been shown to bind peptide sequences that lack the PxxP motif; examples include the PxxDY motif of Eps8 and the RKxxYxxY sequence in SKAP55.
Where are SH3 domains found in the human genome?
Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the interactions of proteins involved in the cytoplasmic signaling.