Is it better to have HER2 positive or negative?
While overall the prognosis of HER2-positive tumors tends to be somewhat poorer than for those that are estrogen receptor-positive but HER2-negative, the widespread adoption of HER2 therapies is making a difference in survival rates, as well as reduced risk for recurrence.
What does double negative mean in breast cancer?
When a breast cancer is HER2-negative, it means that the cancerous cells do not contain high levels of the protein HER2. There are many treatment options available for this type of breast cancer, but the prognosis can vary.
Does HER2-negative respond to chemo?
Because the cancer cells lack these proteins, hormone therapy and drugs that target HER2 are not helpful, so chemotherapy (chemo) is the main systemic treatment option. And although TNBC tends to respond well to initial chemo, it tends to come back (recur) more frequently than other breast cancers.
What is the life expectancy of someone with triple negative breast cancer?
5-year relative survival rates for triple-negative breast cancer
| SEER Stage | 5-year Relative Survival Rate |
|---|---|
| Localized | 91% |
| Regional | 65% |
| Distant | 12% |
| All stages combined | 77% |
Does anyone survive triple negative breast cancer?
Survival rates for triple-negative breast cancer The five-year survival rate for someone with localized triple-negative breast cancer, cancer that has not spread beyond the breast, is 91 percent (91 percent as likely as someone without cancer to survive during the five-year period).
Why is triple negative breast cancer so hard to treat?
Triple-negative breast cancer has fewer treatment options than other types of invasive breast cancer. This is because the cancer cells do not have the estrogen or progesterone receptors or enough of the HER2 protein to make hormone therapy or targeted drugs work. If the cancer has not spread to distant sites, surgery is an option.
What is triple negative breast cancer and how is it treated?
Big Changes Coming in Treatment of Triple-Negative Breast Cancer Refining Chemotherapy for TNBC. In a phase 3 trial, 1 labeled Study 301, Halaven (eribulin mesylate) was compared with the chemotherapy capecitabine in previously treated patients with locally advanced or Novel Strategies in TNBC. Androgen Receptor Signaling.
How to survive triple negative breast cancer?
Radiation is another potential treatment for people with triple – negative breast cancer . Radiation targets and kills the cancer cells to stop their growth and spread. Studies suggest that chemotherapy may be the best treatment option for triple – negative breast cancer .
What is the treatment for triple negative breast cancer?
Triple-negative breast cancer is typically treated with a combination of surgery, radiation, and chemotherapy. Chemotherapy, a medicine that kills cancer cells, will likely be the first thing your doctor tries. You can get it by a needle into a vein or in a pill.