Can you open amantadine capsule?
Swallow whole. Do not crush, break, or chew it. You may also open and sprinkle the extended-release capsules on a teaspoonful of soft food, including applesauce. Take all of the medicine right away without chewing.
Can amantadine be cut?
Take amantadine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the extended-release capsules and extended-release tablets whole; do not split, chew, or crush them.
Are amantadine tablets and capsules interchangeable?
-Not interchangeable with other extended-release amantadine products. -Can be taken with or without food. -Patients should swallow the extended-release capsules whole. They should not crush, chew, or divide capsules.
How do you get off amantadine?
Discontinuation of therapy: Abrupt discontinuation may lead to worsening of Parkinson disease symptoms, hyperpyrexia, or changes in mental status. Reduce the dose by one-half for 1 to 2 weeks before discontinuing.
How long does it take for amantadine to leave your system?
The half-life was 17 ± 4 hours (range: 10 to 25 hours). Across other studies, amantadine plasma half-life has averaged 16 ± 6 hours (range: 9 to 31 hours) in 19 healthy volunteers.
What is the half-life of amantadine?
After single dose administration of 25 to 75 mg to 7 healthy, elderly male volunteers, the apparent plasma clearance of Amantadine was 0.10 ± 0.04 L/hr/kg (range 0.06 to 0.17 L/hr/kg) and the half-life was 29 ± 7 hours (range 20 to 41 hours).
What is amantadine 100mg?
Amantadine is used to prevent or treat a certain type of flu (influenza A). If you have been infected with the flu, this medication may help make your symptoms less severe and shorten the time it will take you to get better.
Should amantadine be taken with food?
Amantadine may cause an upset stomach, taking it with food or milk will help. Taking your last dose several hours before bedtime can help prevent insomnia.
How long should you take amantadine?
This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times at day and night.
What was amantadine originally used for?
Amantadine was first used for the treatment of influenza A. After antiviral properties were initially reported in 1963, amantadine received approval for prophylaxis against the influenza virus A in 1976.
What are the benefits of amantadine?
Why it’s used. Amantadine oral capsule is used to treat a variety of movement disorders caused by Parkinson’s disease. It can also be used to treat movement disorders caused by certain drugs (drug-induced movement disorders). In addition, this drug is used to prevent and treat influenza A virus infection.
How many capsules of amantadine can you take in one day?
The adult daily dosage of amantadine hydrochloride capsules is 200 mg; two 100 mg capsules as a single daily dose. The daily dosage may be split into one capsule of 100 mg twice a day. If central nervous system effects develop in once-a-day dosage, a split dosage schedule may reduce such complaints.
What is the purpose of amantadine hydrochloride capsules?
Amantadine hydrochloride capsules are indicated for the prophylaxis and treatment of signs and symptoms of infection caused by various strains of influenza A virus.
Are there any side effects to taking amantadine?
What Are the Side Effects? 1 Nausea. 2 Lightheadedness. 3 Insomnia. 4 Confusion. 5 Hallucinations. 6 (more items)
What is the plasma concentration of amantadine 100 mg?
Amantadine pharmacokinetics were determined in 24 normal adult male volunteers after the oral administration of a single amantadine hydrochloride 100 mg soft gel capsule. The mean ± SD maximum plasma concentration was 0.22 ± 0.03 mcg/mL (range: 0.18 to 0.32 mcg/mL). The time to peak concentration was 3.3 ± 1.5 hours (range 1.5 to 8 hours).