What is inflammatory myopathy?
The inflammatory myopathies aare a group of diseases that involve chronic (long-standing) muscle inflammation, muscle weakness, and, in some cases, muscle pain. Myopathy is a general medical term used to describe a number of conditions affecting the muscles. All myopathies cause muscle weakness.
How do you treat inflammatory myopathy?
The chronic inflammatory myopathies can’t be cured in most adults but many of the symptoms can be treated. Options include medication, physical therapy, and rest. Polymyositis, dermatomyositis, and necrotizing autoimmune nmyopathy are first treated with high doses of corticosteroid drugs such as prednisone.
What is polymyositis with myopathy?
Polymyositis is one of the inflammatory myopathies, a group of muscle diseases that involves inflammation of the muscles or associated tissues, such as the blood vessels that supply the muscles. A myopathy is a muscle disease, and inflammation is response to cell damage.
What is the difference between myopathy and myositis?
Myopathies cause problems with the muscles you use for voluntary movements such as walking or trying to grab something. Patients often have muscle stiffness or weakness. Myositis: This is a type of myopathy that causes inflammation of your muscles, leading to weakness, swelling and pain.
How does myositis affect the brain?
Myositis can cause “brain fog” making concentration, organization, and other related tasks difficult. Myositis causes a variety of symptoms and affects each person differently.
What kind of muscle disease is inflammatory myopathy?
Myopathy is a term used to describe muscle disease. The inflammatory myopathies are a group of diseases that involve chronic muscle inflammation, accompanied by muscle weakness.
How are myofibers affected by inflammatory myopathies?
The inflammation is similar to PM with cytotoxic (CD8-positive) lymphocytes invading and destroying myofibers. The degenerative changes consist of accumulation of myelinoid bodies and amyloid deposition. Affected myofibers have vacuoles or cracks, which contain basophilic granules.
What is the pathogenesis of inflammatory myopathies ( IBM )?
The pathogenesis of IBM is not known but probably involves abnormal protein processing associated with ageing of myofibers, and the deposition of toxic protein polymers that damage myofibers and trigger inflammation. IBM is refractory to immunosuppressive therapy that is used in other inflammatory myopathies.
Which is the most common inflammatory myopathies in children?
Contractures, subcutaneous calcification, intestinal ulceration, and other extramuscular manifestations are frequent in children.Dermatomyositis affects children and adults and is the most common inflammatory myopathy in children.