What is candesartan cilexetil 16 mg used for?
Candesartan is a medicine widely used to treat high blood pressure (hypertension) and heart failure. Candesartan helps to prevent future strokes, heart attacks and kidney problems.
Does candesartan cilexetil cause weight gain?
For migraine prevention, candesartan (Atacand), is as effective as the frequently prescribed beta blocker propranolol (Inderal), a recent study found. Plus candesartan is less likely to cause weight gain than other migraine preventives 2 and is available as a generic.
What is the action of candesartan?
Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis.
Is candesartan bad for kidneys?
Kidney damage warning: This drug may cause kidney damage. People with certain types of kidney damage or heart failure may have a higher risk. Your doctor will check your kidney function while you’re taking candesartan.
Is candesartan hard on the kidneys?
Which is better losartan or candesartan cilexetil for high blood pressure?
In conclusion, candesartan cilexetil, 8 or 16 mg once daily, is an effective and well-tolerated antihypertensive treatment, with a trough-to-peak ratio close to 1.0. Candesartan cilexetil, 16 mg once daily, produces a significantly greater reduction in blood pressure than losartan, 50 mg once daily.
When does candesartan reach its peak serum concentration?
After tablet ingestion, the peak serum concentration (Cmax) is reached after 3 to 4 hours. Food with a high fat content does not affect the bioavailability of candesartan after candesartan cilexetil administration. Total plasma clearance of candesartan is 0.37 mL/min/kg, with a renal clearance of 0.19 mL/min/kg.
What is the elimination half life of candesartan?
Candesartan is mainly excreted unchanged in urine and feces (via bile). It undergoes minor hepatic metabolism by O-deethylation to an inactive metabolite. The elimination half-life of candesartan is approximately 9 hours.