Where is the EGFR gene located?
EGFR (Epidermal Growth Factor Receptor)
| Alias (NCBI) | ERBB (erb-b2 receptor tyrosin kinase) |
|---|---|
| LocusID (NCBI) | 1956 |
| Atlas_Id | 147 |
| Location | 7p11.2 [Link to chromosome band 7p11] |
| Location_base_pair | Starts at 55019017 and ends at 55171037 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping EGFR.png] |
What type of gene is EGFR?
GeneCards Summary for EGFR Gene EGFR (Epidermal Growth Factor Receptor) is a Protein Coding gene. Diseases associated with EGFR include Inflammatory Skin And Bowel Disease, Neonatal, 2 and Lung Cancer. Among its related pathways are PI3K/AKT activation and Development Slit-Robo signaling.
What type of receptor is EGFR?
Epidermal growth factor receptors are a type of receptor tyrosine kinase. Also called EGFR, ErbB1, and HER1.
What is EGFR gene mutation?
An EGFR mutation refers to a mutation (damage) to the portion of the DNA in a lung cancer cell which carries the “recipe” for making EGFR (epidermal growth factor receptor) proteins.
What is the Met gene?
A gene that makes a protein that is involved in sending signals within cells and in cell growth and survival. Mutated (changed) forms of the MET gene may cause abnormal cells to grow and spread in the body.
Is EGFR a gene or protein?
A gene that makes a protein that is involved in cell growth and cell survival. Mutated (changed) forms of the EGFR gene and protein have been found in some types of cancer, including non-small cell lung cancer. These changes may cause cancer cells to grow and spread in the body.
How does EGFR mutation occur?
Somatic mutations in the EGFR gene most often occur in a type of lung cancer called non-small cell lung cancer, specifically a form called adenocarcinoma. These mutations are most common in people with the disease who have never smoked.
Is EGFR a tumor suppressor gene?
EGFR and KRAS are reported to be the most frequently altered driver genes, while TP53 is reported to be the most frequently altered tumor suppressor gene in lung adenocarcinoma (Cancer Genome Atlas Research Network 2014; Campbell et al. 2016).
Is EGFR gene mutation hereditary?
In some lung cancer patients this gene, called “EGFR”, contains a DNA change known as an “inherited EGFR mutation”. Early data indicate that these inherited EGFR mutations may be associated with an increased risk of lung cancer. So far, only a small number of families have been found to carry inherited EGFR mutations.
What is the difference between c-Met and MET?
c-met or c-Met (all symbols written in italic!) is referred to the gene; in this case to a proto-oncogene because of the presence of “c-” in the symbol. MET is the abbreviation of Mesenchymal to Epithelial Transition (biological process).