What does macrophage migration inhibitory factor do?
Macrophage migration inhibitory factor (MIF) is a pleiotropic cardiokine involved in many immune responses associated with sepsis, I/R injury, atherosclerosis,199 and AMI. The protein has chemokine-like functions and promotes the production of inflammatory mediators including TNF-α, IL-8, and IL-6.
What is MIF gene?
MIF (Macrophage Migration Inhibitory Factor) is a Protein Coding gene. Diseases associated with MIF include Rheumatoid Arthritis, Systemic Juvenile and Systemic Onset Juvenile Idiopathic Arthritis. Among its related pathways are Cell cycle Role of SCF complex in cell cycle regulation and Innate Immune System.
What is MIF cytokine?
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature 365, 756–759 (1993). The rediscovery of MIF as a pro-inflammatory pituitary protein released in response to exposure to endotoxins.
How do macrophages migrate?
Macrophages utilize two types of motility in a 3D environment—amoeboid and mesenchymal. Amoeboid migration is adhesion-independent movement that is based on flowing and squeezing. This migratory mode was shown to be dominant for neutrophils, dendritic cells and lymphocytes (12).
What is the macrophage migration inhibiting factor that keeps macrophages in the local area of infection and inflammation?
Macrophage migration inhibitory factor (MIF) was originally identified in the culture medium of activated T lymphocytes as a soluble factor that inhibited the random migration of macrophages. MIF is now recognized to be a multipotent cytokine involved in the regulation of immune and inflammatory responses.
Do macrophages migrate?
Although they differentiate into heterogeneous populations, depending upon their tissue of residence, motility is an important aspect of their function. To facilitate their migration through tissues, macrophages express a unique range of adhesion and cytoskeletal proteins.
What is macrophage movement?
Macrophages show amoeboid movement. The cytoplasm slides and forms a pseudopodium in front to move the cell forward. Ciliary movement in the human body is observed in the fallopian tubes and respiratory tract.
What does migration inhibitory factor do?
Macrophage migration inhibitory factor (MIF) functions as a pleiotropic protein, participating in inflammatory and immune responses. MIF was originally discovered as a lymphokine involved in delayed hypersensitivity and various macrophage functions, including phagocytosis, spreading, and tumoricidal activity.
Are lymphoid follicles in the walls of the small intestine that produce macrophages?
also known as aggregated lymphatic follicles, are found in the walls of the small intestines. They resemble tonsils and produce macrophages. Their macrophages destroy bacteria and prevent bacteria from penetrating the walls of the small intestines.