How rare is KLS?

How rare is KLS?

KLS is very rare, occurring at a rate of 1 in 1 million, which limits research into genetic factors. The condition primarily affects adolescent males, though females can also be affected and the age of onset varies.

What is the rarest sleep disorder?

Kleine-Levin Syndrome (KLS), also known as “Sleeping Beauty” syndrome, is a rare neurological disorder characterised by recurrent bouts of hypersomnolence (excessive sleeping) along with cognitive and behavioural problems during wakefulness.

Is KLS hereditary?

The exact cause of Kleine-Levin syndrome is not known. However, researchers believe that in some cases, hereditary factors may cause some individuals to have a genetic predisposition to developing the disorder.

How long does Kleine-Levin syndrome last?

It is characterized by recurring but reversible periods of excessive sleep (up to 20 hours per day). Symptoms occur as “episodes,” typically lasting a few days to a few weeks. Episode onset is often abrupt, and may be associated with flu-like symptoms.

Is Klein’s disease Real?

Kleine-Levin syndrome (KLS) is a rare disorder that causes recurring periods of excessive sleepiness. In some cases, this means up to 20 hours a day are spent sleeping. For this reason, the condition is commonly referred to as “sleeping beauty syndrome.” KLS can also produce changes in behavior and confusion.

Can Kleine Levin be cured?

Treating Kleine-Levin Syndrome There is no specific, definitive treatment to cure or control KLS. Some aspects of the disease can be managed with medication, such as stimulants to combat the EDS, but this is most effective only once the episodes have already decreased in severity.

What is fatal familial insomnia?

Fatal familial insomnia (FFI) is a rare genetic degenerative brain disorder. It is characterized by an inability to sleep (insomnia) that may be initially mild, but progressively worsens, leading to significant physical and mental deterioration.

What is Klein’s disease?

Klein’s Syndrome, also known as Waardenburg Syndrome, is a rare genetic disorder that is characterized by deafness, defects in structures arising from the neural crest, nose deformities and skin, iris and hair pigmentation abnormalities.

Can a person sleep for days?

For people who suffer from hypersomnia, oversleeping is actually a medical disorder. The condition causes people to suffer from extreme sleepiness throughout the day, which is not usually relieved by napping. It also causes them to sleep for unusually long periods of time at night.

What are the 5 major sleep disorders?

5 Major Sleep Disorders

• Restless Legs Syndrome (RLS) RLS is a condition that causes your legs to move or shake because of an unpleasant sensation.
• Insomnia.
• REM Sleep Behavior Disorder (RBD)
• Sleep Apnea.
• Narcolepsy.

How many people have Kleine Levin?

It affects around 1/500 000 individuals. Patients are mostly male (68-78% of cases) and adolescents (81% of patients), with a mean age of onset of 15 years (range 4-82 years).

Can you survive FFI?

FFI is usually fatal in 6-36 months. Almost all cases of FFI occur due to a specific variant in the PRNP gene and are inherited in an autosomal dominant pattern. Diagnosis is based on the symptoms, clinical exam, sleep study, and imaging studies. The results of genetic testing can help confirm the diagnosis.

What do you need to know about Kleine Levin syndrome?

View Full Treatment Information. Definition. Kleine-Levin syndrome is a rare disorder that primarily affects adolescent males (approximately 70 percent of those with Kleine-Levin syndrome are male). It is characterized by recurring but reversible periods of excessive sleep (up to 20 hours per day).

Is the Kleine Levin Syndrome Foundation tax deductible?

Please consider donating today! Kleine-Levin Syndrome Foundation, Inc. is a 501 (3)c non-profit organization and all contributions are tax deductible. All funds go directly to support KLS Foundation projects.

What do you need to know about KLS disorder?

KLS is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world where the patient becomes progressively drowsy and sleeps for most of the day and night, sometimes waking only to eat or use the bathroom.