Is PLGA soluble in DCM?
PLGA containing less than 50% glycolyl units (glycolic acid units) is soluble in most common organic solvents, such as halogenated hydrocarbons (chloroform and dichloromethane), ethyl acetate, acetone, dioxan, and tetrahydrofuran.
What is PLGA soluble in?
PLGA can be processed into almost any shape and size, and can encapsulate molecules of virtually any size. It is soluble in wide range of common solvents including chlorinated solvents, tetrahydofuran, acetone or ethyl acetate [7,10]. In water, PLGA biodegrades by hydrolysis of its ester linkages (Figure 2).
How do you dissolve PLGA?
PLGA is naturally amorphous (not crystalline). While poly(lactic) and poly(glycolic) acid are poorly soluble in most solvents, PLGA dissolves in many common solvents including tetrahydrofuran, acetone, ethyl acetate and chlorinated solvents.
Is PLGA soluble in DMF?
which dissolve PLGAs regardless of L:G ratios (acetone, acetonitrile, anisole, chloroform, dichloro- methane, dimethylformamide, dimethylsulfoxide, ethyl acetate, and dioxane) and non-solvents which do not dissolve PLGAs (castor oil, ethanol, decanol, diethyl ether, hexane, lactic acid, and methanol).
Does Plga dissolve in DMSO?
2.2. An amount of 15 mg of PLGA were dissolved in 7.5 mL of DMSO and subsequently 700 L of a solution of RA in DMSO (100 mg/mL), 470 L of a solution of Pluronic F-127 in water (10 mg/mL), and 1 mL of water were added drop wise to the above solution.
Is PLGA hydrophobic or hydrophilic?
PLGA is relatively hydrophobic, necessitating the use of organic solvents for formulation [18]. It is soluble in numerous organic solvents including tetrahydrofuran, chlorinated solvents, acetone or ethyl acetate [24].
What type of copolymer is PLGA?
PLGA is a linear copolymer that can be prepared at different ratios between its constituent monomers, lactic (LA) and glycolic acid (GA) (Figure 1). Figure 1. Chemical structure of poly(lactic-co-glycolic acid) and its monomers.
Does PLGA dissolve in DMSO?
Is PLGA hydrophobic?
PLGA is relatively hydrophobic, necessitating the use of organic solvents for formulation [18]. It is soluble in numerous organic solvents including tetrahydrofuran, chlorinated solvents, acetone or ethyl acetate [24]. The biocompatibility of PLGA has been well investigated and documented.
Is PLGA polar?
Nanoprecipitation. In this method, PLGA and the drug is dissolved in a polar, water miscible solvent and added dropwise to the aqueous phase, which may contain a surfactant.
Is PLGA a random copolymer?
Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable copolymer that is also acceptable for use in a variety of biomedical applications. Typically, a random PLGA polymer is synthesized in a bulk batch polymerization using a tin-based catalyst at high temperatures.
How is PLGA synthesized?
PLGA is synthesized by means of ring-opening co-polymerization of two different monomers, the cyclic dimers (1,4-dioxane-2,5-diones) of glycolic acid and lactic acid. Polymers can be synthesized as either random or block copolymers thereby imparting additional polymer properties.
What kind of solvent is used to make PLGA?
PLGA can be processed into almost any shape and size, and can encapsulate molecules of virtually any size. It is soluble in wide range of common solvents including chlorinated solvents, tetrahydofuran, acetone or ethyl acetate [7,10].
How are the physical properties of PLGA determined?
PLGA physical properties themselves have been shown to depend upon multiple factors, including the initial molecular weight, the ratio of lactide to glycolide, the size of the device, exposure to water (surface shape) and storage temperature [11].
How is dichloromethane used as a solvent?
Used as a solvent and paint remover. Dichloromethane is a member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine.
How is PLGA a biocompatible and biodegradable polymer?
PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer.