What is a category 1B carcinogen?
A category 1A (Carc1A) carcinogen is a substance known to have carcinogenic potential for humans, classification is largely based on human evidence. A category 1B (Carc1B) is a substance which is presumed to have carcinogenic potential for humans, classification is largely based on animal evidence.
What does a group 1 carcinogen mean?
Carcinogenic to humans
Group 1: “Carcinogenic to humans” There is enough evidence to conclude that it can cause cancer in humans. The exposure circumstance entails exposures that are carcinogenic to humans.” “This category is used when there is sufficient evidence of carcinogenicity in humans.
How do you classify carcinogens?
International Agency for Research on Cancer (IARC)
- Group 1: Carcinogenic to humans.
- Group 2A: Probably carcinogenic to humans.
- Group 2B: Possibly carcinogenic to humans.
- Group 3: Not classifiable as to its carcinogenicity in humans.
What are Group 2 carcinogens?
International Agency for Research on Cancer Group 2A: Probably carcinogenic to humans
- Acrylamide.
- Adriamycin (doxorubicin)
- Androgenic (anabolic) steroids.
- Art glass, glass containers, and press ware (manufacture of)
- Azacitidine.
- Biomass fuel (primarily wood), emissions from household combustion.
What are the groups of carcinogens?
The details of the classifications are as follows:
- Group 1: Carcinogenic to humans. Sufficient evidence in humans.
- Group 2A: Probably carcinogenic to humans.
- Group 2B: Possibly carcinogenic to humans.
- Group 3: Not classifiable as to its carcinogenicity to humans.
- Group 4: Probably not carcinogenic to humans.
What is a class C carcinogen?
Group C – Possibly Carcinogenic to Humans: Agents with limited animal evidence and little or no human data. Group D – Not Classifiable as to Human Carcinogenicity: Agents without adequate data either to support or refute human carcinogenicity.
What does it mean to be in Group B1?
Usually, Group B1 is reserved for agents for which there is limited evidence of carcinogenicity from epidemiological studies. It is reasonable, for practical purposes, to regard an agent for which there is “sufficient evidence of carcinogenicity ” in animals as if it presented a carcinogenic risk to humans.
Which is Group 1 agents are carcinogenic to humans?
Radionuclides, beta-particle-emitting, internally deposited (Note: Specific radionuclides for which there is sufficient evidence for carcinogenicity to humans are also listed individually as Group 1 agents) Tamoxifen (Note: There is also conclusive evidence that tamoxifen reduces the risk of contralateral breast cancer in breast cancer patients)
Is the aflatoxin B1 a carcinogen in humans?
Aflatoxins are carcinogenic to humans and animals. Overall summary evaluation of carcinogenic risk to humans is Group 1 (IARC, 1976; Searle, 1976; Dominguez-Malagon & Gaytan-Graham (2001). Aflatoxin B1 is a potent liver carcinogen in a variety of experimental animals.
What do you mean by possible human carcinogen?
Group C: “Possible Human Carcinogen”. “This group is used for agents with limited evidence of carcinogenicity in animals in the absence of human data. It includes a wide variety of evidence, e.g., (a) a malignant tumor response in a single well-conducted experiment that does not meet conditions for sufficient evidence,…