What toxin does Vibrio cholerae produce?
Cholera Toxin B Subunit
Cholera Toxin B Subunit Cholera toxin (CT) is a bacterial protein toxin produced by Vibrio cholerae, which binds to cellular membranes with high affinity.
Is cholera toxin phage coded?
The key toxin of V. cholerae responsible for the life-threatening diarrheal disease cholera, the cholera toxin, is coded by part of the genome of a filamentous phage, CTXϕ. CTXϕ can replicate only in the limited number of Vibrio species.
What is the name of cholera toxin?
Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. It is a member of the Heat-labile enterotoxin family.
What shape is Vibrio cholera?
Vibrio cholerae, the pathogenic bacterium responsible for the diarrheal disease cholera, adopts a characteristic “comma”-shaped cell morphology.
How does cholera produce toxin?
Cholera diarrhoea is due to the action of a toxin that acts on all animal cells by stimulating the enzyme adenylate cyclase, which catalyses the production oc cyclic AMP from ATP. The receptor for cholera toxin on the cell membrane appears to be a complex containing the ganglioside GGnSLC (or GM1).
What is the function of cholera toxin?
Cholera Toxin in Action The catalytic portion of cholera toxin performs a single function: it seeks out the G proteins used for cellular signaling and attaches an ADP molecule to them. This converts the G-protein into a permanently active state, so it sends a never-ending signal.
Where is cholera toxin encoded?
cholerae, cholera toxin, is encoded in the genome of an integrated prophage CTXΦ11,12. Furthermore, different variants of the phage CTXΦ exist, which participate in the genetic diversity of epidemic causing cholera strains13–15.
How the gene encoding cholera toxin becomes part of the bacterial genome?
Lysogenic bacteria phages- which of the following best explains how the gene encoding the cholera toxin becomes part of the bacterial genome? The bacteriophage inserts the toxin gene into the host cell DNA, and the gene is expressed with the rest of the host cell’s genes.
What is the basic effect of cholera toxin?
The basic effect of the cholera toxin is signal amplification. (The effect of the toxin is to prevent the inactivation of the G protein. Because the modified G protein is unable to hydrolyze GTP to GDP, it remains stuck in its active form, continuously stimulating adenylyl cyclase to make cAMP.
How cholera toxin causes diarrhea?
A bacterium called Vibrio cholerae causes cholera infection. The deadly effects of the disease are the result of a toxin the bacteria produces in the small intestine. The toxin causes the body to secrete enormous amounts of water, leading to diarrhea and a rapid loss of fluids and salts (electrolytes).
Is Vibrio rod shaped?
Vibrio is a genus of Gram-negative bacteria, possessing a curved-rod (comma) shape, several species of which can cause foodborne infection, usually associated with eating undercooked seafood.
What is the classification of cholera?