What is the difference between CMML-1 and CMML-2?

What is the difference between CMML-1 and CMML-2?

CMML-1: Blasts make up less than 5% of white cells in the blood and less than 10% of the cells in the bone marrow. CMML-2: Blasts make up 5% to 20% of the white cells in the blood, or they make up 10% to 20% of the cells in the bone marrow.

What is the survival rate for CMML?

Overall, CMML patients have a median overall survival of 20-40 months with highly heterogeneous subgroups contained within the overarching diagnosis. Multiple scoring systems have been developed to better predict which patients will do better or worse.

How quickly does CMML progress?

CMML can develop into an acute myeloid leukaemia (AML) if the number of blast cells in your blood rises above 20%. Doctors call this transformation. Transformation happens in between 15 and 30 out of every 100 people with CMML (between 15 to 30%). This might happen after a few months or after several years.

Can CMML be misdiagnosed?

Together, MDS and CMML may be misdiagnosed and inappropriately managed without a BM confirmation.

How long can a person with CMML live without treatment?

In one study of CMML patients diagnosed between 1975 and 2005, the median survival times with CMML-1 and CMML-2 were 20 months and 15 months, respectively. However, some patients lived much longer. About 20% of CMML-1 patients and about 10% of CMML-2 patients survived longer than 5 years.

How high are monocytes in CMML?

A common sign of CMML is a high number of monocytes, greater than 1,000 per microliter.

Can CMML affect the brain?

Histopathological report confirmed brain infiltration with myeloid leukemic cells. Expert commentary: Despite its rarity, cerebral dissemination should be considered even in patients with CMML.

What is the prognosis for CMML-2 patients?

Untreated CMML-2 patients display a rapid and extremely high rate of transformation supporting a transitional phase to AML. Further, the majority of untreated CMML-2 patients that did not pathologically transform had a particularly poor prognosis clinically consistent with aggressive AML.

Which is better CMML 1 or CMML 2?

Patients with CMML-1 tend to live longer than those with CMML-2. In one study of CMML patients diagnosed between 1975 and 2005, the median survival times with CMML-1 and CMML-2 were 20 months and 15 months, respectively.

Which is better acute myeloid leukemia or CMML-2?

Also, patients with CMML-2 are more likely to go on to develop acute leukemia than patients with CMML-1. In the same study, 18% of CMML-1 patients and 63% of CMML-2 patients developed acute myeloid leukemia within 5 years of their CMML diagnosis. In addition to the type of CMML, other factors may be helpful in predicting survival.

What are the three subtypes of CMML?

The three subtypes are: CMML-0, a category for cases with 2 percent blasts in the blood and 5 percent blasts in the bone marrow. CMML-1, for cases with 2 to 4 percent blasts in the blood and/or 5 to 9 percent blasts in the bone marrow.