What is recombinant albumin?
Recombinant human albumin (rHA) is a highly purified animal-, virus-, and prion-free product developed as an alternative to human serum albumin (HSA), to which it is structurally equivalent. The present investigation compared the safety, tolerability, and pharmacokinetics/pharmacodynamics of rHA with HSA.
What is recombinant human albumin used for?
Its main clinical use is in maintaining colloid oncotic pressure and increasing circulating plasma volume with the typical dosage in excess of 10 g per dose. HSA is isolated by fractionating human plasma, which entails possible contamination by viruses or prions.
What does the term recombinant mean?
genetic recombination
1 : relating to or exhibiting genetic recombination recombinant progeny. 2a : relating to or containing genetically engineered DNA. b : produced by genetic engineering recombinant bovine growth hormone.
What is human serum albumin and recombinant albumin?
Human serum albumin (HSA) is the most abundant protein found in human blood plasma. It is produced in the liver. Recombinant human serum albumin (rHSA) is genetically engineered and derived from a rice-based expression system.
What is a recombinant albumin Molecular Biology Grade?
Recombinant Albumin, Molecular Biology Grade, is a non-bovine derived albumin that can serve as an alternative to Bovine Serum Albumin (BSA). Like BSA, it has been shown to prevent adhesion of enzymes to reaction tubes and pipette surfaces.
How is recombinant human serum albumin ( RHSA ) produced?
HSA is isolated by fractionating human plasma, which entails possible contamination by viruses or prions. Recombinant HSA (rHSA) has been successfully produced using a methylotrophic yeast, Pichia pastoris.
Can a recombinant albumin be used as an alternative to BSA?
Recombinant Albumin that can serve as an alternative to BSA, which can prevent adhesion of enzymes to reaction tubes and pipette surfaces as well as stabilizes some proteins during incubation. Please inquire about custom formulations with Recombinant Albumin.
What is the role of serum albumin in plasma?
Human serum albumin (HSA) is responsible for 80% of the colloid osmotic pressure of plasma (25-33 mmHg). Its main clinical use is in maintaining colloid oncotic pressure and increasing circulating plasma volume with the typical dosage in excess of 10 g per dose.