How do you administer linezolid?
Method of administration: The recommended linezolid dosage should be administered intravenously twice daily. Route of administration: Intravenous use. The solution for infusion should be administered over a period of 30 to 120 minutes.
How do you administer linezolid IV?
How to use Linezolid Solution, Intravenous. This medication is given by injection into a vein as directed by your doctor, usually every 12 hours. It should be injected slowly over 30 minutes to 2 hours. The dosage is based on your medical condition and response to treatment.
What are the side effects of linezolid 600 mg?
What Are Side Effects Associated with Using Linezolid?
- diarrhea.
- vomiting.
- headache.
- red blood cell deficiency.
- low blood platelet count.
- nausea.
- abdominal pain.
- loose stools.
How strong is linezolid?
Dosing. The dosage regimen for linezolid is 400 mg or 600 mg every 12 hours for a duration of 10 to 28 days, with an intravenous or oral route of administration, based on the indication (Table 4).
What should I monitor with linezolid?
Monitoring parameters include heart rate, blood pressure, blood glucose, weekly complete blood count (CBC), and visual function. Blood pressure requires close monitoring in patients with untreated hyperthyroidism.
When do you use linezolid?
As emphasized earlier, linezolid should be reserved for the treatment of patients with infections caused by multidrug-resistant bacteria that are proved by laboratory testing, and to life-threatening or complicated infections associated with multiple resistances to first-line treatments.
What is the half life of linezolid?
The elimination half-life of linezolid is 5-7 hours, and twice-daily administration of 400-600 mg provides steady-state concentrations in the therapeutic range. Linezolid is mainly cleared by non-renal clearance to two metabolites and renal clearance of the parent compound.
When should I stop linezolid?
in patients receiving linezolid for more than 14 days and treatment should be discontinued if there is evidence of myelosuppression.
How many milligrams of linezolid should I take?
The dose is usually 10 milligrams (mg) per kilogram (kg) of body weight every 8 or 12 hours as determined by your doctor. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
When to take linezolid for nosocomial pneumonia?
Usual Pediatric Dose for Nosocomial Pneumonia. Less than 7 days, gestational age less than 34 weeks: 10 mg/kg IV or orally every 12 hours. Less than 7 days, gestational age at least 34 weeks: 10 mg/kg IV or orally every 8 hours. 7 days through 11 years: 10 mg/kg IV or orally every 8 hours. 12 years or older: 600 mg IV or orally every 12 hours.
When to discontinue linezolid after 5 weeks?
Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 5 weeks of monitoring, whichever comes first.
When to start linezolid on a pre-term baby?
Neonates less than 7 days: Most pre-term neonates less than 7 days of age (gestational age less than 34 weeks) have lower systemic linezolid clearance values and larger AUC values than many full-term neonates and older infants. These neonates should be initiated with a dosing regimen of 10 mg/kg every 12 hours.