What is the mechanism of action of vincristine?
The mechanism of action of vincristine sulfate has been related to the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. Central nervous system leukemia has been reported in patients undergoing otherwise successful therapy with vincristine sulfate.
What is the mechanism of action of vincristine and vinblastine?
Both vincristine and vinblastine bind to the microtubular proteins of the mitotic spindle and prevent cell division during the anaphase of mitosis. They arrest mitosis and cause cell death. The drugs are therefore M-phase cell-cycle specific and their effects are therefore limited to dividing cells.
How does vincristine show its action as anticancer agent?
Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
What is the action of vinca?
The mechanism of action of vinca alkaloids is to arrest dividing cells in metaphase by binding tubulin and preventing its polymerization into microtubules. This is also the proposed mechanism of causing neuropathy by inhibiting anterograde and retrograde axonal transport, thereby causing axonal degeneration.
What is the purpose of vincristine?
Vincristine is used in combination with other chemotherapy drugs to treat certain types of leukemia (cancer of the white blood cells), including acute myeloid leukemia (AML, ANLL) and acute lymphoblastic leukemia (ALL), Hodgkin’s lymphoma (Hodgkin’s disease), and non-Hodgkin’s lymphoma (types of cancer that begin in a …
What are the functional groups of vincristine?
It is a methyl ester, an acetate ester, a tertiary alcohol, a member of formamides, an organic heteropentacyclic compound, an organic heterotetracyclic compound, a tertiary amino compound and a vinca alkaloid.
What is the difference between vincristine and vinblastine?
Vinblastine is used to treat Hodgkin’s disease (a form of lymphoid cancer), while vincristine is used clinically in the treatment of children’s leukaemia. Vincristine is more neurotoxic than vinblastine.
What does vincristine do to cells?
How it works. Vincristine is a chemotherapy drug that belongs to a group of drugs called vinca alkaloids. Vincristine works by stopping the cancer cells from separating into 2 new cells. So, it stops the growth of the cancer.
What is the mode of action for the anthracycline anticancer agents?
Mechanism of Action The most widely accepted explanation for the action of anthracyclines is their interaction with topoisomerase-II. The ternary complex thus formed prevents the re-ligation of the ds-DNA breaks. Subsequently, it promotes growth arrest and apoptotic cell death.
What is the mechanism of action of antimetabolites?
Antimetabolites are called a “cytotoxic” type of drug because they kill cells. They work by mimicking the molecules that a cell needs to grow. Cells are tricked into taking in the drugs and then using the antimetabolites instead of their normal building blocks of genetic material: RNA and DNA.
What are the chemical properties of vincristine?
Physiochemical Properties
| S. NO. | PHYSICAL AND CHEMICAL PROPERTIES | |
|---|---|---|
| 1 | Molecular weight | 825 g/mol |
| 2 | Appearance | White crystalline solid |
| 3 | Melting point | 220 °C |
| 4 | Solubility | 2.27 mg per liter in water |
The mechanism of action of vincristine has been related to the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. Patients with the demyelinating form of Charcot-Marie-Tooth syndrome should not be given vincristine.
Which is the correct name for the drug vincristine?
Vincristine DRUG NAME: VINCRISTINE SYNONYM(S)1,2: LCR; Leurocristine; VCR COMMON TRADE NAME(S)1: ONCOVIN® CLASSIFICATION:Mitotic inhibitor, cytotoxic Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Vincristine is a naturally occurring vinca alkaloid.
What does vincristine do to the mitotic spindle?
Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
How is vincristine used in veterinary oncology?
Vincristine is widely used in veterinary oncology. Almost all combination chemotherapy protocols for canine, feline and ferret lymphoma incorporate vincristine into the drug cycle. Remission can be induced with vincristine-containing protocols in cases of chronic lymphocytic leukemia and acute lymphoblastic leukemia.