What is mucoadhesive delivery system?
Mucoadhesive drug delivery systems are delivery systems which utilize the property of bioadhesion of certain polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time.
How do mucoadhesive agents work?
Mucoadhesive agents work through a strong adherence to damaged tissues and physically seal bleeding wounds. Chitosan-based products, available from multiple manufactures, are examples of this type of agent. These include HemCon Bandage, ChitoGauze and Celox Gauze, to name a few.
What is the characteristic of mucoadhesive system in Grdds?
Mucoadhesive formulations contain adhesive biopolymers that adhere to the mucosa covering the stomach inner wall and release their API in a sustained manner [7][8][9][10]. …
What is the principle of Mucoadhesion?
Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood.
What are mucoadhesive materials?
Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems.
What is mucoadhesive agent?
Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. For example, in drug delivery systems, the mucus layer must be penetrated in order to effectively transport micro- or nanosized drug particles into the body.
What is Gastroretentive drug delivery system?
Gastro retentive delivery systems are designed to be retained in the stomach for a prolonged time and release their active ingredients and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal (GI) tract.
What is mucoadhesive drug delivery system Slideshare?
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption. Mucoadhesive drug delivery system is a part of controlled delivery system.
What are mucoadhesive properties?
Molecules that can present mucoadhesive properties are molecules with hydrogen bond building groups, high molecular weight, flexible chains, and surface active properties. as the diffusion coefficient of the mucoadhesive material in the mucus.
What are mucoadhesive polymers?
Mucoadhesive polymers are water-soluble and water insoluble polymers. Mucoadhesive polymers that adhere to the mucin-epithelial surface can be conveniently divided into three broad classes: • Polymers that become sticky when placed in water and owe their mucoadhesion to stickiness.
How does Bioadhesion work?
Bioadhesion refers to the phenomenon where natural and synthetic materials adhere to biological surfaces. An understanding of the fundamental mechanisms that govern bioadhesion is of great interest for various researchers who aim to develop new biomaterials, therapies and technological applications such as biosensors.
What is used as mucoadhesive polymer?
The mucoadhesive polymers used for the ocular delivery include thiolated poly(acrylic acid), poloxamer, celluloseacetoph- thalate, methyl cellulose, hydroxy ethyl cellulose, poly(amidoamine) dendrimers, poly(dimethyl siloxane) and poly(vinyl pyrrolidone) [55–57].
How are mucosal surfaces used in drug delivery?
Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus. Adhesion of a matter to this layer is hence called mucoadhesion. Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug delivery purposes.
How are Mucoadhesive agents used in drug delivery?
Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug delivery purposes.
How is mussel adhesive used in drug delivery?
Mucosal drug delivery applications. For example, films of mussel adhesive protein give comparable mucoadhesion to polycarbophil, a synthetic hydrogel used to achieve effective drug delivery at low drug doses.
How is mucoadhesion related to the Pharmaceutical Sciences?
When relating this mechanism to the pharmaceutical sciences, mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract (GI-tract), the vagina, the lung, the eye, etc.