What is the 2nd line antibiotic for pneumonia?

What is the 2nd line antibiotic for pneumonia?

Children aged 2–59 months with severe pneumonia1 should be treated with parenteral ampicillin (or penicillin) and gentamicin as a first-line treatment. Ceftriaxone should be used as a second-line treatment in children with severe pneumonia having failed on the first-line treatment.

Is double-coverage of Gram-negative organisms necessary?

Double-coverage of suspected Gram-negative pathogens is rarely indicated. 3-8 For example, Gram-negative monotherapy is appropriate if the antibiotic is expected to be active against ≥90% of Gram-negative bacilli.

When is Pseudomonas coverage needed?

The IDSA 2016 guidelines recommend double-coverage for pseudomonas if any of the following criteria are met: (a) prior IV antibiotic use within 90 days, (b) septic shock, (c) ARDS, (d) VAP developing more than four days after hospitalization, (e) acute renal replacement therapy prior to VAP, (f) patients in units where …

What antibiotics are Pseudomonas aeruginosa resistant to?

aeruginosa currently shows resistance to the following antibiotics: penicillin G; aminopenicillin, including those combined with beta-lactamase inhibitors; first and second generation cephalosporins; piperacillin; piperacillin and tazobactam; cefepime; ceftazidime; aminoglycosides; the quinolones; and the carbapenems; …

Does doxycycline cover Pseudomonas aeruginosa?

Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 were used as control strains. Testing against the P. aeruginosa strains revealed high MIC50 values for all the drugs except colistin. Doxycycline and colistin were both effective against the A.

Does levofloxacin cover Pseudomonas?

In conclusion, according to the in vitro activity, levofloxacin could be considered a good option for the treatment of infections sustained by Pseudomonas aeruginosa, and clinical experiments are required to corroborate our in vitro data.