How will you prepared benzofuran from salicylaldehyde?
Benzofurans can be prepared by various methods in the laboratory. Notable examples include: O-alkylation of salicylaldehyde with chloroacetic acid followed by dehydration (cyclication) of the resulting ether and decarboxylation.
What is the use of benzofuran?
Benzofuran derivatives are an important heterocyclic compounds that are possess vital biological activities such as antidepressant, anticancer, antiviral, antifungal, antioxidant, anti-psychotic etc.
Is benzofuran aromatic?
Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.
Which of the following is a benzofuran derivative?
Amiodarone, an iodinated benzofuran derivative, was approved in the United States in 1985 for the treatment of life-threatening ventricular tachyarrhythmias [16].
Which antiarrhythmic drug is benzofuran derivative and having iodine in side chain?
How does amiodarone work in VT?
It is used to restore normal heart rhythm and maintain a regular, steady heartbeat. Amiodarone is known as an anti-arrhythmic drug. It works by blocking certain electrical signals in the heart that can cause an irregular heartbeat.
Where does amiodarone work?
Amiodarone belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep your heart rhythm normal. This medicine is available only with your doctor’s prescription.
How is benzofuran prepared at the 2 position?
Benzofuran is lithiated selectively at the 2-position using alkyllithium reagents, and 3-lithio derivatives (although thermally unstable) can be prepared by halogen–metal exchange. However, the application of such methodology to the direct synthesis of ketone derivatives is conspicuously lacking.
Is there a metal free synthesis of benzofurans?
Synthesis of Benzofurans. A convenient metal-free cyclization of ortho-hydroxystilbenes into 2-arylbenzofurans and 2-arylnaphthofurans is mediated by hypervalent iodine reagents. Using stoichiometric (diacetoxyiodo)benzene in acetonitrile, desired products can be isolated in good yields.
How is benzofuran synthesis from salicylaldehydes 1 and 2?
Benzofuran synthesis from salicylaldehydes 1 and α-haloketones 2 via intramolecular aldol reaction of intermediate of 3.
How does the reaction with diols produce benzofuran?
The reaction with diols delivers benzofuran derivatives via dehydrative C-H alkenylation and annulation reaction. The catalytic C–H coupling method employs cheap starting materials, exhibits a broad substrate scope, and liberates water as the only byproduct.