What does macrophage colony stimulating factor do?
Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R) promotes the differentiation of myeloid progenitors into heterogeneous populations of monocytes, macrophages, dendritic cells, and bone-resorbing osteoclasts.
What produces macrophage colony stimulating?
“Macrophage colony-stimulating factor is produced by activated T lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes”. Blood.
What drug stimulates the production of white blood cells?
Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.
What is the function of CSF-1 in macrophages?
Colony-stimulating factor-1 receptor (c-fms) The macrophage colony-stimulating factor, CSF-1 (M-CSF), is a homodimeric glycoprotein required for the lineage-specific growth of cells of the mononuclear phagocyte series. Apart from its role in stimulating the proliferation of bone marrow-derived precursors of monocytes and macrophages, CSF-1 act …
How is colony stimulating factor 1 receptor linked to MPs?
Colony stimulating factor 1 receptor has been shown to interact with: 1 Cbl gene, 2 FYN, 3 Grb2, 4 Suppressor of cytokine signaling 1, This receptor is also linked with the cells of MPS. More
How does colony stimulating factor 1 affect microglia?
The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
What kind of receptor is CSF1R in mouse?
View/Edit Mouse. Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS).