What can a deficiency in cobalamin vitamin B12 cause?
Vitamin B12 or B9 (commonly called folate) deficiency anaemia occurs when a lack of vitamin B12 or folate causes the body to produce abnormally large red blood cells that cannot function properly. Red blood cells carry oxygen around the body using a substance called haemoglobin.
Is B12 a metabolism booster?
B12 works by converting the food we eat into sugar and other types of fuel that keep the body running smoothly. B12 is often associated with weight loss because of its ability to boost metabolism and provide lasting energy.
What is the role of cobalamin in metabolism?
Cobalamin is a cofactor as adenosylcobalamin in the conversion of methylmalonyl-CoA to succinyl-CoA by L-methylmalonyl-CoA-mutase (mutase) and as methylcobalamin in the remethylation reaction of homocysteine to methionine by methionine synthase (MS).
How does vitamin B12 affect metabolism?
Although research in humans is still very limited, some studies suggest that vitamin B12 could affect body fat and metabolism. One review concluded that vitamin B12 plays a key role in fat metabolism, noting that a deficiency could be linked to increased fat accumulation and obesity ( 3 ).
What causes cobalamin deficiency?
Cobalamin deficiency may result from dietary insufficiency of vitamin B12; disorders of the stomach, small bowel, and pancreas; certain infections; and abnormalities of transport, metabolism, and utilization (see Etiology). Deficiency may be observed in strict vegetarians.
What autoimmune disease causes pernicious anemia?
Intrinsic factor normally binds B12 and facilitates absorption in the intestinal tract. Pernicious anemia is often caused by autoimmune damage to the stomach lining (autoimmune gastritis) in which case the gastric epithelial lining is damaged or destroyed1.
Can vitamin B12 deficiency cause weight gain?
People with vitamin B12 deficiency are likely to experience a wide range of symptoms, though weight gain is unlikely one of them.
What is the function of B12 cobalamin?
Vitamin B12, also called cobalamin, is one of 8 B vitamins. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B complex vitamins, also help the body use fats and protein.
What is the most common cause of cobalamin deficiency?
The most frequent cause of cobalamin malabsorption is pernicious anemia [14] in which the atrophy of the gastric parietal cells results in a lack of secretion of both IF and chlorhydric acid.
What are the biochemical effects of vitamin B12?
Although cobalamin (vitamin B12) was isolated almost 60 years ago, its biochemical, physiologic and neurologic effects remain incompletely defined. New observations suggest renal regulation of cobalamin metabolism; actions of cobalamin on nucleic acid and protein function; and a role for cobalamin i …
What is the role of cobalamin in the body?
New observations suggest renal regulation of cobalamin metabolism; actions of cobalamin on nucleic acid and protein function; and a role for cobalamin i … Although cobalamin (vitamin B12) was isolated almost 60 years ago, its biochemical, physiologic and neurologic effects remain incompletely defined.
Is there a gold standard for diagnosis of cobalamin deficiency?
New observations suggest renal regulation of cobalamin metabolism; actions of cobalamin on nucleic acid and protein function; and a role for cobalamin in cytokine and growth factor regulation. Clinically, no gold standard has emerged for the diagnosis of cobalamin deficiency.
Can a cobalamin deficiency cause renal insufficiency?
Moreover, cobalamin resistance may occur in diabetes, renal insufficiency and advanced age, leading to functional cobalamin deficiency despite adequate cobalamin nutriture. Finally, high-dose cobalamin therapy may have salutary pharmacologic effects on neurologic function in a variety of disorders.