Is there a substitute for desmopressin?
Alternatives to desmopressin as pharmacologic therapy for DI include synthetic vasopressin and the nonhormonal agents chlorpropamide, carbamazepine, clofibrate (no longer on the US market), thiazides, and nonsteroidal anti-inflammatory drugs (NSAIDs).
Can dogs take desmopressin tablets?
Desmopressin acetate is the treatment of choice for central diabetes insipidus in both dogs and cats. Because there are a number of different causes of increased water consumption and increased urine production, desmopressin acetate can also be used to help make a diagnosis.
Is desmopressin harmful to dogs?
Desmopressin should not be used in pets that are allergic to it or in pets that are prone to blood clots, such as those with heart disease. It should be used cautiously in pregnant or nursing pets as studies in animals are limited, although its use is likely safe based on the current information.
How much desmopressin can a dog take?
Initial treatment with desmopressin In most cats and smaller dogs, 1 to 2 drops of the intranasal preparation administered once or twice daily are sufficient to control polyuria and polydipsia (see Table below). Larger dogs may require up to 4 to 5 drops twice daily.
Is Stimate available now?
CSL Behring has Stimate nasal spray on back order and the company estimates the product will not be available until 2022.
Can desmopressin cause kidney problems?
However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving desmopressin.
Does desmopressin need to be refrigerated?
After opening, keep the medicine at room temperature and use it within 60 days. Store DDAVP Rhinal Tube in the refrigerator. Do not freeze. If refrigeration is not available, you may keep the closed bottles at room temperature for up to 3 weeks.
What are side effects of desmopressin?
Common side effects of DDAVP include:
- headache,
- nausea,
- upset stomach or stomach pain,
- diarrhea, or.
- flushing of the face (warmth, redness, tingly feeling).
Is Stimate off the market?
On July 21, 2020, Ferring Pharmaceuticals issued a voluntary recall of Stimate (desmopressin) nasal spray due to “superpotency” – in other words, amounts of desmopressin being higher than specified. Stimate is used to treat von Willebrand disease (VWD) and mild hemophilia A.
Is there a generic for Stimate?
Stimate is a brand-name prescription-only drug. Currently, there is no generic version of Stimate on the U.S market.
Should desmopressin be taken with food?
Conclusions: The gastrointestinal absorption of desmopressin is reduced and delayed if administered with or 1.5 hours after a meal. This decreased absorption of desmopressin did not have an impact on the antidiuretic action of the drug since all treatment regimens elicted a maximal response.
How do you give a dog desmopressin nasal spray?
The usual dosage of desmopressin for dogs with central diabetes insipidus is 1 to 2 drops administered to the eyes or nostrils twice a day. The drug is available in tablet form, though it’s less common for dogs to take it orally.