What causes arthrogryposis multiplex?
AMC is thought to be related to decreased movement in utero, which can have multiple causes. Neurologic and muscle problems may well be the most common causes of decreased fetal movement, but connective tissue disorders, maternal illness, and limited space are also common causes.
Can arthrogryposis be detected in utero?
The majority of cases of arthrogryposis that are identified prenatally are ascertained in the second or third trimester. Common findings include decreased fetal movements clenched hands, joint contractures, abnormal extension, or flexion position of limbs (Figure 3A,C,D) and polyhydramnios.
Is arthrogryposis hereditary?
Arthrogryposis is not thought to be a genetic or hereditary condition. The exact cause of arthrogryposis is unknown, but a number of different theories have been proposed: Some believe that arthrogryposis is caused by obstructions to intrauterine movement during pregnancy.
Is arthrogryposis multiplex congenita treatable?
Arthrogryposis is typically discovered in utero or at birth. A medical exam and history are done to diagnose the condition. Additional genetic testing may also be performed to try and find the larger cause. There is no cure for the condition, but treatment options are available to alleviate its symptoms.
Is arthrogryposis multiplex congenita progressive?
What is Arthrogryposis? Arthrogryposis, also called arthrogryposis multiplex congenita (AMC), involves a variety of non-progressive conditions that are characterized by multiple joint contractures (stiffness) and involves muscle weakness found throughout the body at birth.
Can arthrogryposis be seen on ultrasound?
Fetal arthrogryposis detected with prenatal ultrasound imaging is defined as ≥2 joint contractures in >1 body area. Arthrogryposis is not a specific diagnosis but rather is a descriptive term for multiple contractures that can be associated with many different medical conditions.
Is arthrogryposis multiplex congenita life limiting?
In general, many people affected by AMC have a good prognosis. With physical therapy and other available treatments, substantial improvement in joint function and mobility is normally possible. Most people with AMC are of normal intelligence and are able to lead productive, independent lives as adults.