Does NGF prevent apoptosis?

Does NGF prevent apoptosis?

NGF and BDNF protect neuronal apoptosis through Trk signaling. It is well known that activation of Trk receptors play a critical role in promoting cell survival.

Can growth factors trigger apoptosis?

Deprivation of growth factors leads to the induction of apoptosis, i.e. condensa- tion of chromatin and degradation in oligonucleosome- sized fragments, formation of plasma and nuclear mem- brane blebs and cell fragmentation into apoptotic bodies which can be taken up by neighbouring cells.

What triggers neuronal apoptosis?

In vitro studies in primary neuronal cultures have highlighted the importance of the BH3-only proteins Puma and Bim in causing apoptosis in response to a plethora of toxic stimuli, including DNA damage, reactive oxygen species, endoplasmic reticulum stress, proteasomal inhibition, amyloid-β, and excitotoxic stress.

What is NGF for brain?

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.

What does NGF bind to?

Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons.

What is the difference between apoptosis and necrosis?

Apoptosis is described as an active, programmed process of autonomous cellular dismantling that avoids eliciting inflammation. Necrosis has been characterized as passive, accidental cell death resulting from environmental perturbations with uncontrolled release of inflammatory cellular contents.

Does inflammation cause mitochondrial dysfunction?

Experimental evidence supports an intricate association between inflammation and mitochondrial dysfunction as main contributors of neurological diseases.

What happens when growth factors fail?

The failure to compete successfully for growth factors not only prevents cell division but also can lead to the generation of signals that eliminate cells via apoptosis. In addition to promoting proliferation, deregulated growth factor receptor signaling can also result in the suppression of apoptosis.

What happens if there is no growth factor?

Thus, in the absence of growth factors, it appears that IL-3-dependent cells are unable to take up sufficient nutrients to maintain bioenergetic homeostasis.