What are microspheres used for?
Microspheres are spherical microparticles, and are used where consistent and predictable particle surface area is important. In biological systems, a microparticle is synonymous with a microvesicle, a type of extracellular vesicle (EV).
What are advantages of microsphere drug delivery?
Introduction
| No. | Advantages of microspheres |
|---|---|
| 3 | Microspheres produce more reproducible drug absorption. |
| 4 | Drug discharge in stomach is hindered and that’s why local unwanted effects are reduced. |
| 5 | In case of microspheres, better therapeutic effect for short half-life of drugs can be achieved. |
How are microspheres administered?
Microspheres of a diameter that allows them to be contained in the microcirculation without separating from the bloodstream during circulation (usually 15 μm) are injected into the arterial circulation (either systemic or specific to the organ of interest), and the tissue is subsequently harvested and the number or …
What is the meaning of microspheres?
A very tiny, hollow, round particle made from glass, ceramic, plastic, or other materials. Microspheres injected into blood vessels that feed a tumor may kill the tumor by blocking its blood supply.
How are microspheres made?
Microsphere are made from glass, ceramic, carbon or plastic depending on applications. Solid glass microsphere is manufactured by direct burning of glass powders while hollow glass microspheres is produced by adding blowing agent to glass powder.
How are microspheres formed?
Commonly, microspheres have been formed by coagulating the alginate solution in the form of fine droplets using calcium chloride solution (Martinsen et al. Non-aggregated alginate microspheres with an average diameter of 8 µm have been produced via an emulsification process (see Fig. 15b) by Lemoine et al. (1998).
How do you prepare microspheres?
[6] Chitosan microspheres have been prepared by emulsion crosslinking, ion-induced coagulation, and spray-drying methods. Of these methods, the most common method used to prepare chitosan microspheres is the emulsion chemical crosslinking method.
What are the components of Tdds?
Polymer matrix, drug, permeation enhancers are the main components of TDDS; Polymers include gelatine, gum Arabic, methyl cellulose, starch, shellac, etc. (as a natural) to synthetic ones (polyethylene, polystyrene, acetyl co-polymer, polyvinyl chloride, polyamide, polyvinyl acetate, etc.)
What is a microsphere formulation?
The term MICROSPHERE is defined as a spherical particle with size varying from 50nm to 2µm, containing a core substance. Microspheres are, in strict sense, spherical empty particles. Spheres and spherical particles are also usedfor a large size and rigid morphology.
Who invented microsphere?
Sidney W. Fox
| Sydney Fox | |
|---|---|
| Born | 24 March 1912 Los Angeles |
| Died | 10 August 1998 (aged 86) Mobile, Alabama |
| Known for | Microspheres |
| Scientific career |
What is the chemical composition of microspheres?
According to the research findings, heavy fraction microspheres contain aluminosilicate ferrous composition, iron oxides and, less often, native iron. The particle size ranges between 50 and 150 μm. The structural and textural features of the microspheres are quite diverse.
What is the composition of microspheres?
Microspheres are small, spherical particles usually made up of biodegradable and biocompatible polymers having the size ranging from 1 to 1000 μm and incorporating drugs and other bioactive within their core [202].
What is nano drug delivery system?
Perhaps the most publicized use of nanotechnology in drug delivery under development is the use of nanoparticles to deliver drugs to cancer cells. Particles are engineered so that they are attracted to diseased cells, which allows direct treatment of those cells. This technique reduces damage to healthy cells in the body.
What is ocular drug delivery system?
Ocular Iontophoresis: Lantophoresis is a new concept in ocular drug delivery system in which charged drug molecules are used. Positive charge drug molecules were driven into the tissue at anode and negative charge drug molecule driven respectively at cathode. Ocular lantophoresis is safe, fast and easy.
What is automated drug delivery system?
Automated Drug Delivery System Drug delivery refers to approaches, formulatons, technologies, and systems for transportng a pharmaceutcal compound in the body as needed to safely achieve its desired therapeutc effect .
What is a medication delivery system?
Drug delivery systems are methods which are used to ensure that drugs get into the body and reach the area where they are needed. These systems must take a number of needs into account, ranging from ease of delivery to effectiveness of the drugs.