What does a positive anti SSB mean?
A positive result for SS-B/La antibodies is consistent with connective tissue disease, including Sjogren syndrome and lupus erythematosus.
What happens if ENA test is positive?
Interpretation of results for the tests included in an ENA panel are provided in the table below. A positive test result means that the person has more of that autoantibody in their blood than the designated reference value.
What does a positive ENA and ANA test mean?
An anti-ENA screen is usually prescribed following a positive result in an antinuclear antibody (ANA) test. While the ANA test suggests the presence of an autoimmune disorder, an anti-ENA panel makes it possible to distinguish between many different collagen diseases.
What does an ENA blood test show?
An ENA (Extractable Nuclear Antigen Antibodies) panel detects the presence of one or more specific autoantibodies in the blood. Autoantibodies are produced when a person’s immune system mistakenly targets and attacks the body’s own tissues.
What is SSB in medicine?
Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene….Sjögren syndrome antigen B.
| SSB | ||
|---|---|---|
| showGene ontology | ||
| Orthologs | ||
| Species | Human | Mouse |
| Entrez | 6741 | 20823 |
What is SSB in blood work?
What it is: Anti-Ro(SSA) and Anti-La(SSB) are two antibodies that are commonly found together. They are specific against ribonucleic acid (RNA) proteins. Why the test is used: Anti-Ro is found in anywhere from 24% to 60% of lupus patients.
Can you have a false positive ENA?
The ANA test is very sensitive for the diagnosis of autoimmune diseases but results in many false positives. It has been reported that up to 15% of completely healthy individuals have a positive ANA test without an autoimmune disease and that ANAs are measurable in approximately 25% of the population.
Is a positive ANA test serious?
Results. The presence of antinuclear antibodies is a positive test result. But having a positive result doesn’t mean you have a disease. Many people with no disease have positive ANA tests — particularly women older than 65.
Does positive ANA mean lupus?
A positive result on an ANA test means that antinuclear antibodies were found in your blood. You may get a positive result if: You have SLE (lupus). You have a different type of autoimmune disease.
What cancers cause positive ANA?
Neoplastic diseases may cause positive ANA. Some authors have described that ANA is found in the sera from lung, breast, head and neck cancer patients as frequently as in RA and SLE 3, 4, 5. Chapman et al. 6 has suggested that in breast cancer they may be used as an aid to early diagnosis.
What is the most common connective tissue disorder?
Rheumatoid Arthritis (RA): Rheumatoid arthritis is one of the most common connective tissue diseases and can be inherited. RA is an autoimmune disease, meaning the immune system attacks its own body. In this systemic disorder, immune cells attack and inflame the membrane around joints.
What is dsDNA and Ena testing?
Autoantibodies to nuclear antigens, i.e. antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) and extractable nuclear antigens (ENA), are useful as diagnostic markers for a variety of autoimmune diseases.
What kind of antibodies are used for Ena?
Antibodies to ENA are common in patients with connective tissue diseases (systemic rheumatic diseases). SSA or Ro is composed of protein antigens of 52 kD and 60 kD combined with cytoplasmic RNA species.
What kind of Ena is SS-B / La?
Clinical Information SS-B/La is an extractable nuclear antigen (ENA) composed of a 48-kD protein combined with RNA species.
What does it mean to have a positive SSA antibody?
Interpretation. A positive result for SSA (Ro) or SSB (La) antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis. A positive result for SSA antibodies in a woman with LE prior to delivery indicates an increased risk of congenital heart block in the neonate.
What kind of blood test is the ENA panel?
Extractable Nuclear Antigen (ENA) Panel. The ENA (extractable nuclear antigen) panel is a blood test that looks for antibodies to 6 or 7 different proteins in the body. These antibodies include: anti-Ro (also called anti-SSA) anti-La (also called anti-SSB)