What is interactome networks?
Interactomes are dynamic protein networks in which many protein–protein interactions are context-dependent and require specific modifications and/or structural alterations of the interacting partners that only occur under the appropriate cellular conditions [11,12].
What is interactome data?
Interactomics. Interactomics is a discipline at the intersection of bioinformatics and biology that deals with studying both the interactions and the consequences of those interactions between and among proteins, and other molecules within a cell.
What is meant by proteome?
A proteome is the complete set of proteins expressed by an organism. The term can also be used to describe the assortment of proteins produced at a specific time in a particular cell or tissue type. In addition, proteins undergo modifications, which may occur either before or after translation.
What are Interactomes used for?
The interactome has also been used to characterise the functions of unknown proteins. Usually proteins which interact together are also likely involved in similar or same biological processes. Thus, finding the interacting partners of an unknown protein or metabolite can give indication as to its function.
How big is the human interactome?
A statistical approach to calculating the number of interactions in humans gives an estimate of around 650 000, one order of magnitude bigger than Drosophila and 3 times larger than C. Elegans.
What kind of information can be obtained from an interactome network?
Predicting Disease Related genes using Interactome Networks Physical protein-protein interactome network maps can indeed generate lists of genes potentially enriched for new candidate disease genes or modifier genes of known disease genes (Lim et al., 2006; Oti et al., 2006; Fraser and Plotkin, 2007).
How big is the human Interactome?
Do all cells have proteomes?
The study of the function of proteomes is called proteomics. A proteome is the entire set of proteins produced by a cell type. Even though all cells of a multicellular organism have the same set of genes, the set of proteins produced in different tissues is different and dependent on gene expression.
What cell has a proteome?
The genomes of viruses and prokaryotes encode a relatively well-defined proteome as each protein can be predicted with high confidence, based on its open reading frame (in viruses ranging from ~3 to ~1000, in bacteria ranging from about 500 proteins to about 10,000).
What are the building blocks of proteins?
The building blocks of proteins are amino acids, which are small organic molecules that consist of an alpha (central) carbon atom linked to an amino group, a carboxyl group, a hydrogen atom, and a variable component called a side chain (see below).
What is the transcriptome of a cell?
A transcriptome is the full range of messenger RNA, or mRNA, molecules expressed by an organism. The term “transcriptome” can also be used to describe the array of mRNA transcripts produced in a particular cell or tissue type.
How many gene interactions are there in the interactome?
In 2010, the most “complete” gene interactome produced to date was compiled from about 5.4 million two-gene comparisons to describe “the interaction profiles for ~75% of all genes in the budding yeast”, with ~170,000 gene interactions.
Who was the first person to use the word interactome?
The word “interactome” was originally coined in 1999 by a group of French scientists headed by Bernard Jacq. Mathematically, interactomes are generally displayed as graphs.
Which is the best definition of an interaction?
Interaction is a kind of action that occur as two or more objects have an effect upon one another.
How are the properties of an interactome analyzed?
Once an interactome has been created, there are numerous ways to analyze its properties. However, there are two important goals of such analyses. First, scientists try to elucidate the systems properties of interactomes, e.g. the topology of its interactions. Second, studies may focus on individual proteins and their role in the network.